Constitutive NF-κB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B- cell lymphomas by Lingchen Fu, Yen-Chiu Lin-Lee, Lan V. Pham, Archito Tamayo, Linda Yoshimura, and Richard J. Ford Blood Volume 107(11): June 1, 2006 ©2006 by American Society of Hematology

BLyS is constitutively expressed in aggressive NHL-B cells. Lingchen Fu et al. Blood 2006;107: ©2006 by American Society of Hematology

Constitutive BLyS expression contributes to NHL-B cell survival in vitro. Lingchen Fu et al. Blood 2006;107: ©2006 by American Society of Hematology

Transcription factors NF-κB and NFAT bind to the BLYS promoter. Lingchen Fu et al. Blood 2006;107: ©2006 by American Society of Hematology

Constitutive BLyS expression through the NF-κB pathway activates a positive feedback loop contributing to NHL-B cell survival. Lingchen Fu et al. Blood 2006;107: ©2006 by American Society of Hematology

Inhibition of NFAT activity reduces BLyS protein expression in NHL-B cells. Lingchen Fu et al. Blood 2006;107: ©2006 by American Society of Hematology

Induction of cellular NF-κB and NFAT activation leads to BLyS protein expression in normal B lymphocytes and low-grade follicular lymphoma (FL) cells. Lingchen Fu et al. Blood 2006;107: ©2006 by American Society of Hematology

Both NF-κB and NFAT binding sites in the BLyS promoter are important for its activity. Lingchen Fu et al. Blood 2006;107: ©2006 by American Society of Hematology