Sperm protein 17 (Sp17) is a suitable target for immunotherapy of multiple myeloma by Maurizio Chiriva-Internati, Zhiqing Wang, Emanuela Salati, Klaus.

Slides:

Advertisements

Similar presentations

T cell-mediated immunity Chapter 8

Advertisements

SAP mediates specific cytotoxic T-cell functions in X- linked lymphoproliferative disease by Reza Sharifi, Joanna C. Sinclair, Kimberly C. Gilmour, Peter.

Generating AML-Specific Peripheral Blood Autologous Cytotoxic T-Lymphocytes (CTLs)‏ by Rohtesh S. Mehta, Xiaohua Chen, Antony Jeyaraj, and Paul Szabolcs.

HOST DEFENCE AGAINST TUMORS:

WT1-specific T-cell responses in high-risk multiple myeloma patients undergoing allogeneic T cell–depleted hematopoietic stem cell transplantation and.

Collaboration is required for successful immunotherapy

Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells by Susanne M. Schmidt,

Volume 19, Issue 12, Pages (December 2011)

Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators by Rikke Bæk Sørensen, Sine Reker Hadrup, Inge Marie Svane, Mads Christian.

by Masih Ostad, Margareta Andersson, Astrid Gruber, and Anne Sundblad

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses by Giulia Nizzoli, Jana Krietsch, Anja Weick, Svenja.

Aurora-A kinase: a novel target of cellular immunotherapy for leukemia

Advances in Specific Immunotherapy for Prostate Cancer

T-cell epitopes within the complementarity-determining and framework regions of the tumor-derived immunoglobulin heavy chain in multiple myeloma by Lotta.

MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+precursors by Allan J. Masterson, Claudia C. Sombroek,

by Rafijul Bari, Teresa Bell, Wai-Hang Leung, Queenie P

TCL1: a shared tumor-associated antigen for immunotherapy against B-cell lymphomas by Jinsheng Weng, Seema Rawal, Fuliang Chu, Hyun Jun Park, Rakesh Sharma,

Antigen-Specific CD8 T Cells Can Eliminate Antigen-Bearing Keratinocytes with Clonogenic Potential via an IFN-γ-Dependent Mechanism Rachel L. De Kluyver,

Epstein-Barr virus–specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy by Claudia Rossig,

ALK as a novel lymphoma-associated tumor antigen: identification of 2 HLA-A2.1–restricted CD8+ T-cell epitopes by Lorena Passoni, Antonio Scardino, Carla.

Differentiation and Functions of CD8+ Effector T Cells

Human NK cell development in NOD/SCID mice receiving grafts of cord blood CD34+ cells by Christian P. Kalberer, Uwe Siegler, and Aleksandra Wodnar-Filipowicz.

Simultaneous Ex Vivo Expansion of Cytomegalovirus and Epstein-Barr Virus–Specific Cytotoxic T Lymphocytes Using B-Lymphoblastoid Cell Lines Expressing.

HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells by Ennio Carbone, Paola Neri,

Ex vivo induction of multiple myeloma–specific cytotoxic T lymphocytes

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

Rapid generation of combined CMV-specific CD4+ and CD8+ T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants by Georg.

CD8+ cytotoxic T lymphocytes isolated from allogeneic healthy donors recognize HLA class Ia/Ib–associated renal carcinoma antigens with ubiquitous or restricted.

Cytokine and chemokine expression of flucloxacillin-specific T cell clones (TCC) of patient P1. Cytokine and chemokine expression of flucloxacillin-specific.

Antigen-induced regulatory T cells

by Loïc Dupré, Grazia Andolfi, Stuart G

Antigen Presenting Phenotype of Hodgkin Reed-Sternberg Cells: Analysis of the HLA Class I Processing Pathway and the Effects of Interleukin-10 on Epstein-Barr.

Induction of myeloma-specific cytotoxic T cells using dendritic cells transfected with tumor-derived RNA by Caterina Milazzo, Volker L. Reichardt, Martin.

Mature dendritic cells pulsed with freeze–thaw cell lysates define an effective in vitro vaccine designed to elicit EBV-specific CD4+ and CD8+ T lymphocyte.

by Douglas D. Ross, Judith E. Karp, Tar T. Chen, and L. Austin Doyle

Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15 by Maria Wysocka, Bernice M. Benoit, Sarah.

Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection by Katherine K. Wynn, Zara.

Colorectal cancer vaccines: Principles, results, and perspectives

HLA-A*0201+ Plasmacytoid Dendritic Cells Provide a Cell-Based Immunotherapy for Melanoma Patients Caroline Aspord, Marie-Therese Leccia, Dimitri Salameire,

Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell–depleted stem cell transplantation.

Volume 130, Issue 2, Pages (February 2006)

Lymphoma spread? Target CD47-SIRPα!

Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma by Carmen Choi, Mathias Witzens, Marianna.

Gene expression and immunologic consequence of SPAN-Xb in myeloma and other hematologic malignancies by Zhiqing Wang, Yana Zhang, Haichao Liu, Emanuela.

Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses by Cagan Gurer, Till.

Adoptive Cellular Therapy using Cells Enriched for NKG2D+CD3+CD8+T Cells after Autologous Transplantation for Myeloma Kenneth R. Meehan, Laleh Talebian,

A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin by Christina Trambas, Federico.

FLT3 ligand administration after hematopoietic cell transplantation increases circulating dendritic cell precursors that can be activated by CpG oligodeoxynucleotides.

by Cunren Liu, Shaohua Yu, John Kappes, Jianhua Wang, William E

HIV-specific effector cytotoxic T lymphocytes and HIV-producing cells colocalize in white pulps and germinal centers from infected patients by Anne Hosmalin,

Cytomegalovirus-Specific Cytotoxic T Lymphocytes Can Be Efficiently Expanded from Granulocyte Colony-Stimulating Factor–Mobilized Hemopoietic Progenitor.

Mutated regions of nucleophosmin 1 elicit both CD4+ and CD8+ T-cell responses in patients with acute myeloid leukemia by Jochen Greiner, Yoko Ono, Susanne.

Generation of Highly Cytotoxic Natural Killer Cells for Treatment of Acute Myelogenous Leukemia Using a Feeder-Free, Particle-Based Approach Jeremiah.

Cytokine-Release Syndrome in Patients With B-Cell Chronic Lymphocytic Leukemia and High Lymphocyte Counts After Treatment With an Anti-CD20 Monoclonal.

Induction of chronic lymphocytic leukemia (CLL)–specific CD4- and CD8-mediated T-cell responses using RNA-transfected dendritic cells by Martin R. Müller,

HLA-A*0201+ Plasmacytoid Dendritic Cells Provide a Cell-Based Immunotherapy for Melanoma Patients Caroline Aspord, Marie-Therese Leccia, Dimitri Salameire,

Circulating Natural Killer Lymphocytes Are Potential Cytotoxic Effectors Against Autologous Malignant Cells in Sezary Syndrome Patients Jean-David Bouaziz,

Drug Specific Cytotoxic T-Cells in the Skin Lesions of a Patient with Toxic Epidermal Necrolysis Amal Nassif, Armand Bensussan, Nicolas Bachot, Martine.

A comparison of gene transfer and antigen-loaded dendritic cells for the generation of CD4+ and CD8+ cytomegalovirus-specific T cells in HLA-A2+ and HLA-A2−

Volume 13, Issue 2, Pages (February 2006)

Cytokine-Induced Memory-Like Differentiation Enhances Unlicensed Natural Killer Cell Antileukemia and FcγRIIIa-Triggered Responses Julia A. Wagner, Melissa.

Cord Blood Nucleated Cells Induce Delayed T Cell Alloreactivity

Restoration of the Expression of Transports Associated with Antigen Processing in Human Malignant Melanoma Increases Tumor-Specific Immunity Juan Tao,

The Telomerase Catalytic Subunit Is a Widely Expressed Tumor-Associated Antigen Recognized by Cytotoxic T Lymphocytes Robert H Vonderheide, William C.

Vaccines for Lung Cancer

CD16 uses additional pathways for killing.

by Martin Felices, Behiye Kodal, Peter Hinderlie, Michael F

Cytotoxicity of p5399–107-induced CTL cells.

Distributions of CD4, Th1, and Th2 in adults (n = 16; A) and children (n = 50; B). Distributions of CD4, Th1, and Th2 in adults (n = 16; A) and children.

Patient Tregs express normal levels of suppression.

Presentation transcript:

Sperm protein 17 (Sp17) is a suitable target for immunotherapy of multiple myeloma by Maurizio Chiriva-Internati, Zhiqing Wang, Emanuela Salati, Klaus Bumm, Bart Barlogie, and Seah H. Lim Blood Volume 100(3): August 1, 2002 ©2002 by American Society of Hematology

Successful generation of Sp17-specific CTLs from PBMCs of patients with MM.Sp17-specific CTLs lysed autologous DC pulsed with Sp17 recombinant protein but not the control target cells. Maurizio Chiriva-Internati et al. Blood 2002;100: ©2002 by American Society of Hematology

Target cell killing with EBV-transformed autologous LCLs.When Sp17-specific CTLs from patient 1 were used as effector cells against autologous LCLs pulsed with Sp17 recombinant protein, target lysis was observed in LCLs pulsed with the recombinant protein a... Maurizio Chiriva-Internati et al. Blood 2002;100: ©2002 by American Society of Hematology

Sp17 recombinant protein-primed CTLs could lyse autologous tumor cells expressing Sp17.Tumor cell cytotoxicity by CTLs could be blocked by a monoclonal antibody directed at monomorphic HLA class I molecules but not HLA class II molecules (patients 1-3 were... Maurizio Chiriva-Internati et al. Blood 2002;100: ©2002 by American Society of Hematology

Blocking of tumor cell lysis.Tumor cell lysis by Sp17 recombinant protein-primed CTLs derived from patient 1 could be blocked by autologous Sp17+ LCLs but not Sp17− LCL (LCL/tumor cell ratio, 40:1), confirming the specificity of the tumor cell kill. Maurizio Chiriva-Internati et al. Blood 2002;100: ©2002 by American Society of Hematology

Flow cytometric analysis of the CTL lines showed that they were made up predominantly of CD8+ T cells, most of which were CD56−. Maurizio Chiriva-Internati et al. Blood 2002;100: ©2002 by American Society of Hematology

Flow cytometric analysis for intracellular cytokines showed that the CTL line produced predominantly IFN-γ and very little IL-4. Maurizio Chiriva-Internati et al. Blood 2002;100: ©2002 by American Society of Hematology

Autologous tumor cell lysis by Sp17-specific CTLs could be blocked by CMA but not Brefeldin A, suggesting that target cell cytotoxicity was mediated via the perforin pathway. Maurizio Chiriva-Internati et al. Blood 2002;100: ©2002 by American Society of Hematology