September 2016

2 RayOne® fully preloaded IOL injection system, designed to deliver without compromise What you want: A design that can deliver an IOL consistently With expert control Through a micro incision with minimal wound stretch The market challenge: Current preloaded IOL systems have sought to answer the surgeon’s need through enhancing one element: the lens or injector. This can result in a trade off between ease of use or surgical outcomes A product designed to respond to your needs: the inspiration behind the new RayOne® Design the system as one – lens and injector together –MICS lens and unique patented Lock & Roll TM technology created as part of the same design process Smallest fully preloaded injector (1.65 mm nozzle) New RayOne® MICS lens is enhanced version of the tried-and-tested C-flex and Superflex platform –Combined into a single 6 mm optic design –Material and design benefits retained –No compromise on proven stability or optical performance

Easy-to-use, true 2-step system Simple and intuitive –Minimal learning curve –Minimises error Increase efficiencies –Designed to enable repeatability –Reduces operating time 3 Step 1. Insert OVD into cartridge via port Step 2. Lock cartridge ready for implantation True 2-step system Single handed plunger with minimal force required Ergonomic design for ease of handling Unique patented Lock & Roll™ technology for consistent delivery Sub 2.2 mm incision

RayOne® enhanced 6.0 mm optic 4 Available as spheric or aberration-neutral aspheric optic Based on proven haptic technology for excellent stability 1,2 Amon-Apple enhanced square edge for minimal PCO (1.7% at 24 months 7 ) Zero glistenings Largest fully preloaded power range on the market D to D

5 Lock & Roll technology™ A smoother, more consistent rolling and delivery of the lens via micro incision Rolls the lens to under half its size before injection –Consistent, smoother delivery –Reduces insertion forces Fully enclosed cartridge with no lens handling –Reduces the risk of lens damage –Minimises chance of contamination Consistently locked and rolled to under half its size in one simple action

6 The smallest fully preloaded injector nozzle, enabling true micro incision 1.65 mm RayOne® nozzle Smallest fully preloaded injector nozzle –Ease of insertion –Compatible with MICS Parallel sided for minimal stretch –Sub 2.2 mm wound-in delivery –Maintains incision architecture

7 RayOne® Plunger safety Plunger designed with safety built-in It cannot advance until after cartridge is locked A safety clip is not required, reducing risk of oversight and also, time Before the cartridge is closed, the plunger (in red) can’t advanced through to the IOL chamber, because the bore in the cartridge (in blue) is not aligned Once the clips have been fully engaged, the cartridge is closed and the bore is aligned and ready to receive the plunger

When considering an intraocular lens, what’s important to you? 8

9 Reliable optical outcomes and a low rate of post-operative complications Designed with Rayner’s Anti-Vaulting Haptic (AVH) Technology®. Our RayOne® IOL provides proven rotational and centrational stability, and excellent fixation in the capsular bag 1 Superb centration –Maximum offset of only 1 mm 3 months after surgery 2 Excellent rotational and torsional stability –3.1° mean IOL rotation 3 months after surgery 2 360° Optimised Barrier to reduce PCO – Low Nd: YAG capsulotomy rates Rayner’s 360° Amon-Apple Enhanced Square Edge creates an optimum barrier to reduce epithelial cell migration including at the haptic-optic junction 7,5 Biocompatible hydrophilic acrylic material, with a long-term record of safety Over 5 million lenses sold since the first C-flex Aspheric in Low silicon oil adherence 9 Excellent uveal biocompatibility 13 Low inflammatory response 10

10 Aberration-neutral technology for optimal visual quality and functional visual acuity in all light conditions The RayOne® Aspheric IOL has been designed with an aspheric anterior surface that creates no spherical aberration. Studies have demonstrated that aberration-neutral technology: Offers improved contrast sensitivity compared with spherical IOLs 3,4 Provides better low-light level visual acuity than spherical IOLs 14 Can offer more depth of field that aberration-negative IOLs by retention of the patient’s natural level of corneal spherical aberration 6 Are less susceptible to the effects of decentration than aberration-negative IOLs 11 Twice as many patients* preferred the aberration-neutral IOL than aberration-negative 6 Three times fewer reports of visual disturbances with the aberration-neutral IOL than aberration-negative 6 Poor depth of field – no residual SA Good depth of field with retained Spherical Aberration *Of those who expressed a preference

11 Vacuole free material for a glistening free IOL Single piece IOL created from Rayacryl®: an homogeneous material free of microvacuoles, resulting in a glistening free IOL 8 Compressible material for delivery through a micro incision Excellent handling characteristics with controlled unfolding within the capsular bag Vision without glareVision affected by glare Reducing dysphotopsia by design 12 Rayner’s Enhanced Square Edge Technology shows no general increase in glare from previous models without a square edge 7 The low refractive index (1.46) of Rayacryl®

12 Technical Information RayOne® Aspheric IOL Optic Diameter:6.00mm Overall Length:12.50 mm Estimated A-constant:118.6 (optical biometry) Power Range:-10.0 D to +7.0 D (1.0 D increments, inc. plano) +8.0 D to D (0.5 D increments) D to D (1.0 D increments) Material:Single piece Rayacryl® hydrophilic acrylic (26% water content in equilibrium) UV Protection:Benzophenone UV absorbing agent UV Light Transmission:UV 10% cut-off is 380 nm Refractive Index:1.46 Asphercity:Anterior aspheric surface with aberration-neutral technology Optic Diameter:Biconvex (positive powers), Bioconcave (negative powers) Optic Edge Design:Amon-Apple 360° enhanced square edge Haptic Angulation:0°, uniplanar Haptic Style:Closed loop with anti-vaulting hatpic (AVH) technology RayOne® Delivery System Injector Nozzle Size:1.65 mm Incision Size:2.2 mm

13 Recommended for use with Ophteis® FR Pro: Sodium Hyaluronate & Sorbitol -A viscous cohesive designed to exceed core OVD requirements and enhance endothelial protection during surgery -In addition to a 2% NaHa concentration, FR Pro contains 4% sorbitol, a proven free radical scavenger -During a three-second phaco time study, FR Pro showed greater overall average cell protection (28.4% less cell death) compared to three market-leading OVDs*. -RayOne® also has been validated for use with the entire Rayner Ophteis and Methylvisc OVD ranges, as well as leading competitor OVDs. *University of Brighton, UK, in vitro phaco free radical studies, data to be published.

What does RayOne® give you? True 2-step preloaded system Easy to use Minimises error Increases efficiency Enhanced 6.0 mm optic Minimal PCO Proven technology for excellent stability Zero glistenings One system for the entire power range D to D Consistent through sub 2.2 mm incisions 14

References 1. Claoué C. Clinical and Surgical Ophthalmology 2008; 26(6): Alberdi R et al. J Refract Surg. 2012; 28(10): Nanavaty MA et al. J Cataract Refract Surg. 2009; 35:663– Yagci R et al. Eur J Ophthalmol Jul 24; 24(5): Vyas AV et al. J Cataract Refract Surg 2007; 33: Johansson B et al. J Cataract Refract Surg. 2007; 33:1565– Mathew RG and Coombes AGA. Ophthalmic Surg Lasers Imaging Nov-Dec; 41(6): Rayner. Data on File. White paper 9. McLoone E et al. Br J Ophthalmol. 2001; 85:543– Richter-Mueksch S et al. J Cataract Refract Surg. 2007; 33:1414– Altmann GE et al. J Cataract Refract Surg. 2005; 31(3): Cezón Prieto J and Bautista MJ. J Cataract Refract Surg. 2010; 36: Tomlins PJ et al. J Cataract Refract Surg. 2014; 40:618– Pepose JS et al. Graefes Arch Clin Exp Ophthalmol Jul;247(7): Rayner. Data on file 15

Discover why RayOne® is in a class of its own, visit rayner.com/rayone