Some Bacterial Diseases. Normal Microbial Flora of the Digestive System Mouth 1 ml saliva = millions of bacteria Stomach and small intestine Few organisms.

Slides:



Advertisements
Similar presentations
Gasrtointestinal bacterial infections Gastroentritis *Is the most common form of acute gastrointestinal infection, causing diarrhea with or without vomiting.
Advertisements

Diseases of the gastrointestinal tract
The 12 “Most Unwanted” Bacteria
Pathogenic Enteric Bacteria I
Lecture 17: Microbial diseases of the digestive system Edith Porter, M.D. 1.
Foodborne Illnesses Objective What is a foodborne Illness? A disease transmitted by food Caused by contaminants – Substances that are harmful to.
Bacteria that cause diarrhea and dysentery
Gram Negative Rods of the Enteric Tract
Microbial Diseases of the Digestive System
Lesson 1.5 The Usual Suspects Definitions and templates for: Case Notes 1.5 Investigation Activity 1.5.
Gastroenteritis Inflammation of stomach or intestines –Inhibits nutrient absorption and excessive H 2 O and electrolyte loss Bacterial Viral Parasites.
Infectious Diseases of the Digestive System. GI Tract.
FOOD BORNE DISEASES Lecture Group A
MICROBIAL DISEASES OF THE DIGESTIVE SYSTEM. MOUTH Over 300 types of bacteria Dental caries Periodontal disease –Gingivitis –Periodontitis.
Microbial Diseases of the Digestive System
DIARRHOEAL DISEASES Causes of Over-indulgence in Chemical Long-term antibiotic Viral causes: # Rotavirus # Norwalk.
Food Borne Illnesses What are Food Borne Illnesses? An illness that comes from the ingestion of contaminated food Often called food poisoning Two types:
GIT BLOCK Dr. Ali Somily & Prof. Hanan Habib Department of Pathology KSU.
Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation prepared by Christine L. Case M I C R.
Waterborne Pathogens: Bacteria February 9 th -11 th, 2010.
Digestive Diseases Shigellosis Campylobacter jejuni Cholera.
Microbial Diseases of the Digestive System
Food Microbiology.
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation prepared by Christine L. Case Microbiology.
What happens in the body after the microbes that produce illness are swallowed? After they are swallowed, there is a delay, called the incubation period,
Clinical Microbiology (MLCM- 201) Prof. Dr. Ebtisam. F. El Ghazzawi. Medical Research Institute (MRI) Alexandria University.
Infectious Diarrheas - Overview Greatest cause of morbidity and mortality worldwide Scope of disease: 1993, E.coli 0157:H Cyclospora 1998.
Dr Sabrina Moyo Department of Microbiology and Immunology
The organism is the principal cause of 'Travellers' diarrhoea'. It is also a major cause of dehydrating diarrhoea in infants and children in less.
Infectious foodborne pathogens FS Infectious foodborne bacteria INFECTION Invasion of and multiplication within the body by ‹ Salmonella ‹
Salmonella Gastroenteritis, typhoid fever, paratyphoid fever.
Shigellosis Bacterial dysentery. Microbial Agent Four species of Shigella: –boydii –dysenteriae (causes deadly epidemics) –flexneri (1/3 of U.S.) –sonnei.
Food Pathogens. OVERVIEW Define Food borne Illness Identify common food pathogens that cause food borne illness: BacteriaVirusFungiParasites.
SHIGELLA Important Gram-negative, Lactose negative rods.
Most virulent strain of E. coli Enterohemorrhagic E. coli Symptoms range from mild gastroenteritis with fever to bloody diarrhea About 10% of patients.
The Human Digestive System
Vibrios, Campylobacters and Associated Bacteria
1 ORAL AND GASTROINTESTINAL DISEASES CHAPTER Anatomy Review Mouth Stomach Small Intestine.
Food borne Illness. Objective -Food borne ilness Food Intoxication---def, example Food infection---def, example.
BACILLARY DYSENTERY SHIGELLOSIS
BACTERIAL INFECTIONS OF GIT Assistant Professor Microbiology Syed Yousaf Kazmi College of Medicine, Majmaah University.
 Most strains of Escherichia coli bacteria are harmless and found in the intestines of warm blooded animals.  We need E. coli to breakdown cellulose.
Foodborne Illness Review St. Michael CHS. What am I going to Learn? This is a review of the foodborne illnesses You will learn the major food illnesses.
FOODBORNE ILLNESS FOOD BOURNE INFECTION - CONSUMING PRODUCTS CONTAMINATED WITH PATHOGENIC BACTERIA, PARASITES, OR VIRUSES IE. SALMONELLA, HEPATITIS, E.COLI.
Two types of contamination: –direct contamination –cross-contamination Contamination Basics direct contamination Raw foods, or the plants or animals.
Food Poisoning.
ACUTE GASTROENTERITIS
Όρια ανάπτυξης παθογόνων
Chapter 26 Foodborne Gastroentritis Caused by Salmonella and Shigella
Cholera Cholera is a disease caused by infection with the gram-negative bacterium Vibrio cholerae.
Bacterial Gastroenteritis
Pathology 417 – Case 1: Microbiology Laboratory
Foodborne Illness Review
Contaminates in our Food Supply
Bacteria.
Food borne Pathogens II
Bacterial diseases Microbiology.
Shigellosis Bacterial dysentery.
Dr Mustafa Nema /Baghdad college of Medicine 2014
Enteric Gram-Negative Bacilli
Bacterial Gastrointestinal tract (GIT) infections
Bacteria.
MICROBIAL FOOD SAFETY A FOOD SYSTEMS APPROACH
Microbial Diseases of the Digestive System
CAUSATIVE ORGANISMS OF FOOD-BORNE
اسهال عفوني (Infectious Diarrhea)
Bacillary Dysentery (shigellosis)
The 12 “Most Unwanted” Bacteria
Food Borne Illness.
Campylobacter Microbiology properties Curved (comma- or S-shaped)
Presentation transcript:

Some Bacterial Diseases

Normal Microbial Flora of the Digestive System Mouth 1 ml saliva = millions of bacteria Stomach and small intestine Few organisms due to HCl and rapid movement of food Large intestine 100 billion bacteria per gram of feces 40 % of fecal mass is microbial cell material Lactobacillus, Bacteriodes, Enterobacter, E. coli. Proteus spp.

Bacterial Diseases of Lower G.I. Infections Pathogens enters G.I. Tract and multiples Bacteria may penetrate the intestinal mucosa or may pass to other systemic organs Delay in appearance of symptoms while pathogen increases in number or invades tissue Usually a fever Intoxications Ingestion of a preformed toxin Sudden onset of symptoms ( few hours ) Fever not always present

Bacterial Diseases of Lower G.I. Diarrhea – infections and intoxications Blood or mucus - dysentery Abdominal cramps, nausea and vomiting Defense mechanism to rid body of harmful material Gastroenteritis Inflammation of stomach or intestinal mucosa

Campylobacter Gastroenteritis Campylobacter jejuni Gram (-), microaerophilic spiral Most common cause of food borne illness in the U.S. Found in the intestines of many animals, especially poultry Almost all retail chicken is contaminated 60 % of cattle is contaminated 2 million cases per year

Escherichia Gastroenteritis 1. ETEC - enterotoxigenic E. coli Not invasive Enterotoxin – watery diarrhea 2. EIEC - enteroinvasive E. coli Invades intestinal wall Inflammation, fever & Shigella-like dysentery 3. EHEC - enterhemorrhagic E. coli E. coli O157: H7 Found in intestines of animals, especially cattle Hemorrhagic colitis – inflammation of colon with bleeding HUS – Hemolytic Uremic Syndrome Blood in urine leading to kidney failure (kidneys effected by toxin)

Shigellosis (Bacillary Dysentery) Bacterial infection - Shigella sp. Gram (-), facultative, rods Shigella sonnei Shigella dysenteriae Shigella flexneri Shigella boydii Incubation period: 12 hours to 2 weeks Usually fever Mild case of Shigellosis Traveler’s Diarrhea Montezuma’s Revenge Green Apple Two Step Shigella sonnei

Toxin Shiga toxin - Kiyoshi Shiga Unusually virulent Bacteria invade intestinal mucosa – produce toxin Severe diarrhea with blood in stool (dysentery) Toxin inhibits Protein Synthesis Cells lining G.I. tract are shed Up to 20 bowels movements a day

20,000 – 30,000 cases per year in U.S. 5 – 15 deaths Shigella dysenteriae – more severe - Mortality Rate = 20 %

Salmonellosis (Salmonella Gastroenteritis) Bacterial Infection – Salmonella sp. Salmonella Gram (-), facultative, non-spore forming rods Found in G.I. Tract of humans and many animals All are considered pathogenic Taxonomy Use serotype rather than species Over 2000 serotypes (50 common in U.S.) Salmonella arizonaeSalmonella brazil Salmonella atlantaSalmonella pakistan Salmonella berlinSalmonella california

Salmonellosis Incubation time 12 – 36 hours Bacteria invade the intestinal mucosa and multiply May pass thru mucosa into lymphatic or circulatory system and become systemic Fever, abdominal pain, cramps and diarrhea

Salmonellosis 1 billion Salmonella per gram of feces Mortality rate < 1 % Higher in infants and elderly Recovery in a few days Some may shed bacteria in feces for 6 months

Salmonellosis Contamination Meats, poultry, eggs, pet reptiles (turtles) Undercooked or Raw Eggs Hollandaise sauce Cookie batter Caesar salads “Sunny side up” fried eggs

Typhoid Fever Salmonella typhi - most virulent Salmonella Only found in humans (feces) Systemic disease Spreads thru body, found in blood, urine, feces Mortality rate 1-2 %, used to be 10 % Was common before days of proper sewage treatment Still common in Third World countries

Typhoid Mary Mary Mallon – cook in N.Y. carrier Responsible for several outbreaks and many deaths Refused to leave her job 1 – 3 % become chronic carriers Microbe lives in gallbladder and is shed in feces

Cholera Vibrio cholerae - Gram (-) curved rod Endemic in Asia and India Cholera toxin Secretion of Cl - leads to H 2 O loss and diarrhea 12 – 20 liters of fluid per day ( 3 – 5 gallons)

Food Poisoning from Seafood Vibrio parahaemolytica Found in salt H 2 O estuaries Associated with poisoning from Raw oysters Shell fish Shrimp crabs

Staphylococcal Food Poisoning (Staphylococcal intoxication) Ingesting an enterotoxin by Staph. aureus Staphylococci High resistance to heat Resistant to drying out Resistant to high osmotic pressures Resistant to high salt conc. Found in nasal passages and hands Contaminate food

* 1 million bacteria per gram of food to produce enough enterotoxin to cause illness

Most reliable method of preventing Staphylococcal intoxication: Adequate refrigeration during storage to prevent toxin production Toxin Triggers vomiting reflex center of brain Abdominal cramps & diarrhea Recovery usually complete in 24 hours. Mortality rate – 0 % in healthy people

Peptic Ulcers Helicobacter pylori – microaerophilic spiral 30% - 50 % of normal pop. are infected, but only 15% of those develop ulcers urease H 2 O + urea ammonia + CO 2 Urea Breath Test Swallow radio-active urea If positive, patient will exhale radio-active CO 2 within 30 minutes