Effects of granulocyte-colony stimulating factor on chromosome aneuploidy and replication asynchrony in healthy peripheral blood stem cell donors by Betsy.

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Effects of granulocyte-colony stimulating factor on chromosome aneuploidy and replication asynchrony in healthy peripheral blood stem cell donors by Betsy Hirsch, LeAnn Oseth, Meghan Cain, Erin Trader, Shelley Pulkrabek, Bruce Lindgren, Xianghua Luo, Mary Clay, John Miller, Dennis Confer, Daniel Weisdorf, and Jeffrey McCullough Blood Volume 118(9): September 1, 2011 ©2011 by American Society of Hematology

Mean abnormal aneuploidy cell frequency (of a total 200 cells) and SD for the probes of CEP7, ELN, and D7S486/D7S522 in the control samples (left bar at each time point) and the G-CSF samples (right bar at each time point). Betsy Hirsch et al. Blood 2011;118: ©2011 by American Society of Hematology

Mean abnormal aneuploidy cell frequency (of a total 200 cells) and SD for the chromosome 7 probes ELN and D7S486/D7S522 scored together for loss to identify cells with monosomy 7), for chromosome 8q22 probe RUNX1T1 scored for gain to identify cells with tri... Betsy Hirsch et al. Blood 2011;118: ©2011 by American Society of Hematology

Mean asynchrony cell frequency (of a total 200 cells) and SD for the probes of SNRPN, 15qter, and TP53 in controls (white bars) and G-CSF subjects (black bars). *P <.05. Betsy Hirsch et al. Blood 2011;118: ©2011 by American Society of Hematology