VLPs Products in Creative Biostructure

VLP Lipoparticles have many advantages in isolating membrane proteins: firstly, they are homogeneous and physically well defined, capable of maintaining the native structures of target membrane proteins in high densities; secondly, they can be used to detect membrane protein interactions and therefore have wide applications in antibody screening, phage and yeast display, immunogens production and ligand binding assays. Creative Biostructure uses MemPro™ virus-like particles (VLP) to efficiently isolate membrane proteins in the form of lipoparticles.VLP

VLP product Creative Biostructure provides VLP products containing high concentrations of specific membrane proteins in their native conformation. VLPs capture conformationally- intact membrane proteins directly from the cell surface, enabling these complex proteins to be manipulated as soluble proteins. Our VLPs are produced with specified membrane proteins on a custom basis, or are available from a selected catalog of ReadyVLPs. Sample kits are also available for purchase for preliminary application testing.VLP products

Zika Virus VLP Creative Biostructure develops a safe, effective and straightforward strategy to rapidly produce a Zika vaccine. Our Zika Virus VLPs are composed of partially mature particles containing Envelope (E), pre-Membrane (prM) and Membrane (M). VLPs are produced in mammalian suspension cell cultures offering a suitable system for rapid scale up of manufacturing, without the risk of working with an infectious agent. The lack of infectivity of the product eliminates the need for chemical inactivation, which may compromise vaccine efficacy and safety. The particulate nature of the vaccine and the preservation of a variety of conformational antigenic sites may even render this vaccine efficacious in humans without using adjuvant if its incorporation into a vaccine raises safety concerns. In summary, the Zika VLP platform puts forward a vaccine composition and production system ready for clinical development of a safe and effective prophylactic Zika vaccine, which is greatly needed to meet the challenges imposed by the spread of the Zika epidemic.Zika Virus VLPs

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