Med chem II tutoring Anesthetics Brandy Hollums fdn383@uthsc.edu

Local anesthetics 1. Identify drugs by chemical class 2. Effect of physicochemical properties on the a.) aqueous solubility or the drugs (e.g. lidocaine vs. benzocaine) b.)stability and DOA of the drugs 3. SAR 4. Side effects (i.e. toxicity of Las)

Which class does the following structure belong to? A. Amino Esters B. Amino Amides C. Amino ethers D. Alcohols E. Phenol c. pramoxine

Which class does the following structure belong to? A. Amino Esters B. Amino Amides C. Amino ethers D. Alcohols E. Phenol a. procaine

Which class does the following structure belong to? A. Amino Esters B. Amino Amides C. Amino ethers D. Alcohols E. Phenol d. Benyzl alcohol

Which class does the following structure belong to? A. Amino Esters B. Amino Amides C. Amino ethers D. Alcohols E. Phenol b. lidocaine

Which class does the following structure belong to? A. Amino Esters B. Amino Amides C. Amino ethers D. Alcohols E. Phenol e. phenol

Which statement is true? A. Benzocaine is more stable than lidocaine due to the ester group. B. Lidocaine is more stable than benzocaine due to the ester group. C. Lidocaine is more stable that benzocaine due to the amide group. D. Benzocaine is more stable that lidocaine due to the ester group. C.

Lidocaine vs. benzocaine

Which of the following is true? A. Electron donating groups at the meta and para position increase activity of local anesthetics. B. Electron withdrawing groups at the ortho and para position increase activity of local anesthetics. C. Electron donating groups at the ortho and para positions increase activity of local anesthetics. D. Electron donating groups at the ortho and para positions decrease activity of local anesthetics. c

Which of the following drugs can help maintain local concentrations of lidocaine? A. Albuterol B. Epinephrine C. Dobutamine D. Diazepam b.

Hydrolysis of the amide bond in which LA produces methemoglobinemia? A. Benzocaine B. Pramoxine C. Alcohol D. Prilocaine D.

Inhalation of general anesthetics 1. Effect of blood solubility on induction of anesthesia, recovery from anesthesia, and toxicity of GAs. 2. Ability to produce analgesia and/or muscle relaxation. 3. Side effects: hepatotoxicity, nephrotoxicity, and malignant hyperthermia.

Match game 1. GA w/high blood solubility 2. GA w/medium blood solubility 3. GA w/low blood solubility Intermediate induction and recovery Fast induction and fast recovery Slow induction and slow recovery 1-c, 2-a, 3-b

What side effect is associated with the following GA? A. arrhythmias B. nephrotoxicity C. neurotoxicity D. ototoxicity B. Methoxyflurane

Which of the following GA have limited skeletal muscle relaxation? B a. Methoxyflurane b. nitrous oxide c. diethyl ether

Which of the following is a toxicity of GA due to hypermetabolic reactions in skeletal muscles? A. Hepatotoxicity B. Nephrotoxicity C. Malignant Hyperthermia D. Congenital birth defects C.

Intravenous Anesthetics 1. Recognize the drugs by structure 2. Advantages over inhalation anesthetics 3. Effect of physicochemical properties on aqueous solubility (e.g. propofol) 4. Effect on the cardiovascular and respiratory systems as ability to produce analgesia and muscle relaxation 5. Side effects (e.g. dissociative anesthesia, hallucinations)

Which of the following is accompanied with hallucinations? a. Ketamine (pcp analog)

Which of the following is used to prevent hallucinations caused by ketamine? c. midazolam

Which of the following is not an advantage of IV anesthetics over GA? A. more convenient dosage form B. ease of administration C. lack of flammability D. Rapid onset and prolonged DOA

What class does the following structure belong to? Barbiturates Benzodiazepines Opioids Anti-emetics C.

Which of the following is water soluble? A. Propofol B. Fospropofol B.

Which IV anesthetic produces dissociative anesthesia? A. ketamine B. etomidate C. midazolam D. fentanyl a.

Which iv anesthetic has CV stimulation? A. propofol B. thiopental C. ketamine D. etomidate c.

Which is a major side effect of opioid medications A. diarrhea B. nausea and vomiting C. CNS stimulant D. pruritus b.