(Approved investigational) Drugbank ID : DB00113 Protein average weight : 144482.5000

Half life : Approximately 1 hour Description : Reduced Fab fragment of the murine IgG1 monoclonal antibody IMMU-4 (also called NP-4) with specificity for carcinoembryonic antigen (CEA) covalently labeled with Technitium 99. The molecule has a molecular weight of ~54,000 Daltons. Indication : For imaging colorectal tumors Pharmacodynamics : Binds to the carcinoembryonic antigen, which is a cell surface protein generally overexpressed in colon (and other) cancers. The radioactive Tc99, which is covalently attached to the antibody, allows radiodiagnostic detection of CEA expressing cells and tumors

Metabolism : Most likely removed by opsonization via the reticuloendothelial system, or by human antimurine antibody production Mechanism of action : Binds selectively to cell-surface carcinoembryonic antigen (CEA) expressed on colorectal tumors.

Targets : Affected organisms : Carcinoembryonic antigen-related cell adhesion molecule 1 Affected organisms : Humans and other mammals

Categories : Diagnostic Agents Sequence : >1clo:Anti-CEA heavy chain 1 EVKLVESGGGLVQPGGSLRLSCATSGFTFTDYYMNWVRQPPGKALEWLGFIGNKANGYTT EYSASVKGRFTISRDKSQSILYLQMNTLRAEDSATYYCTRDRGLRFYFDYWGQGTTLTVS SAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQS DLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDCPPCKCPAPNLLGGPSVF IFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLR VVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKK QVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERN SYSCSVVHEGLHNHHTTKSFSR >1clo: Anti-CEA antigen light chain 1 QTVLSQSPAILSASPGEKVTMTCRASSSVTYIHWYQQKPGSSPKSWIYATSNLASGVPAR FSGSGSGTSYSLTISRVEAEDAATYYCQHWSSKPPTFGGGTKLEIKRADAAPTVSIFPPS SEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTL TKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC >1clo:Anti-CEA heavy chain 2 >1clo: Anti-CEA antigen light chain 2

Brands : CEA-Scan Company : Immunomedics Inc Description : CEA is expressed by more than 90% of colorectal cancers, as well as by a large number of other carcinomas, including esophageal, stomach, lung, breast, pancreas, uterus, and ovarian cancer. It has been shown that this tumor marker can serve as a useful target for radiolabeled antibodies. Since CEA-Scan uses a small antibody fragment at a low dose, there is virtually no immune reaction by subjects to the foreign protein. In addition, linking the fragment with technetium-99m, a common radioisotope in nuclear medicine, permits tumor detection within a few hours, using conventional gamma cameras. Used for/Prescribed for : CEA- Scan is used for treating colorectal cancer.

Allergic reaction, mild, transient (itching; skin rash),bursitis (pain and inflammation at the joints),eosinophilia, transient, fever , headache, nausea.

http://www.drugs.com/mmx/cea-scan.html