© Academy Of Infection Management 2015 (All Rights Reserved) Case Study: A patient with a history of alcoholism and bilateral pneumonia

Patient presents to the emergency department A 59-year-old male patient presents to the ED complaining of acute chest pain and productive cough for 24 hours At presentation, he has moderate hypothermia (36.0°C), tachypnoea, tachycardia, SaO2 87% with FiO2 0.4 and BP 80/60 mmHg Laboratory tests reveal: Leukopenia (1100/mm3, mainly polymorphonuclear leukocytes [PMNs]) Anaemia (haematocrit 26.5%, haemoglobin 9.1 g/dL) High erythrocyte sedimentation rate (ESR) (115 mm/first hour) Chest X-rays show extensive infiltrations in the right superior and left medium lung zones © Academy Of Infection Management 2015 (All Rights Reserved)

© Academy Of Infection Management 2015 (All Rights Reserved)

History The patient’s history reveals hospitalisation 2 years ago due to recurrent episodes of coughing and small volume hemoptysis with weight loss He is a mariner (last sailed 6 months ago) and a habitual alcohol drinker A chest CT scan from the previous hospitalisation demonstrates the existence of three cavitational lesions in the right lung © Academy Of Infection Management 2015 (All Rights Reserved)

CT scan results from the hospitalisation 2 years ago © Academy Of Infection Management 2015 (All Rights Reserved)

Laboratory findings and treatment 2 years ago Persistent laboratory investigations fail to confirm a diagnosis of TB Laboratory investigations for vasculitis and other auto-immune diseases are also negative Despite this, he receives empiric anti-TB treatment for 1 month without clinical improvement, but there is radiological deterioration Sputum cultures are not diagnostic and blood cultures are negative Under the presumed diagnosis of aspiration pneumonia, he receives antimicrobial therapy with ciprofloxacin plus clindamycin, after which he has substantial clinical improvement He is discharged from hospital, but does not return for the recommended follow-up © Academy Of Infection Management 2015 (All Rights Reserved)

Patient in ED: Questions What is your differential diagnosis? What is your opinion on the antimicrobial therapy? Which of the following would you include in a combination regimen? Fusidic acid Azithromycin Fluconazole Ampicillin/sulbactam Piperacillin/combactam A carbapenem © Academy Of Infection Management 2015 (All Rights Reserved)

Question What is your recommendation for the patient’s therapy? Consider options other than the antimicrobial therapy © Academy Of Infection Management 2015 (All Rights Reserved)

Clinical course in the ED An empiric combination therapy is commenced with: Fusidic acid Azithromycin Fluconazole Ampicillin/sulbactam During the current hospitalisation, the patient’s condition worsens within hours, necessitating admission to the ICU. He is: Mechanically ventilated Transfused 1 unit of red blood cells Microbiological investigations are performed on blood and bronchial secretions © Academy Of Infection Management 2015 (All Rights Reserved)

Further clinical course He develops galactic (lactic) acidosis, hemodynamic instability, and he spikes a high fever (>39.5°C) and leukocytosis (which gradually reaches 23 000/mm3 with a predominance of PMNs) But then his condition improves and four days later, he is discharged from the ICU as he is: Afebrile, hemodynamically stable with normal blood gases, but with a very slight regression of his leukocytosis (20 000/mm3) © Academy Of Infection Management 2015 (All Rights Reserved)

Further clinical course The next day, his fever recurs Klebsiella pneumoniae is isolated from both blood cultures and bronchial secretions (which had been sent from the ICU) and the tip of the central vein catheter reveals presence of Acinetobacter baumannii © Academy Of Infection Management 2015 (All Rights Reserved)

Results of sensitivity testing Antibiotic K. pneumoniae* A. baumannii Amikacin I R Ampicillin/sulbactam Aztreonam Cefepime Ceftazidime Ciprofloxacin Imipenem Meropenem S Piperacillin/tazobactam Tetracycline Tobramycin TMP/SMX Colimycin © Academy Of Infection Management 2015 (All Rights Reserved) *K. pneumoniae is found to produce extended-spectrum β-lactamase (ESBL) and metallo-β-lactamase (MBL)

Questions The patient is again febrile. What do you think is the reason for this? e.g. consider whether treatment had failed, superinfection etc Which antimicrobial treatment would you recommend now? © Academy Of Infection Management 2015 (All Rights Reserved)

Patient is transferred Due to multiresistant infection, the patient is transferred to the Infection Unit of a tertiary care hospital Upon admission, he is: Febrile (38.8°C), hypoxaemic (PO2 55 mmHg), with leukocytosis (16 200/mm3) but without marked PMN (PMN 78%), ESR 105 mm/first hour, procalcitonin (PCT) 0.17 ng/mL Seriously malnourished and suffering from alcoholic polyneuritis, resulting in an inability to stand or walk © Academy Of Infection Management 2015 (All Rights Reserved)

Clinical course A new sputum culture is obtained He receives combination antibiotic therapy with meropenem 1g x 3 IV and colimycin 2 MU x 3 IV and 1 MU x 3 by inhalation Three days later, his fever is slightly reduced (~38°C), leukocytes have decreased to 12 700/mm3 and he is hemodynamically stable A chest CT scan reveals bilateral cavitations © Academy Of Infection Management 2015 (All Rights Reserved)

Chest CT scan results © Academy Of Infection Management 2015 (All Rights Reserved)

Test results Amplified Mycobacterium tuberculosis direct test (Gen-Probe) and Ziehl-Neelsen smear are negative Non-quantitative sputum culture reveals presence of MRSA Question: What is your suggestion now? © Academy Of Infection Management 2015 (All Rights Reserved)

Empiric therapy remains the same The empiric regimen is not modified Three days later, the patient is again afebrile with normal blood gases and a normal leukocyte count During the following days, he has gradual radiological improvement Nevertheless, he remains unable to rise from his bed; he has a coarse tremor and very severe muscle atrophy The total duration of antimicrobial therapy is 15 days Two days later, he is transferred to a rehabilitation centre and re-evaluation is requested after 3 months © Academy Of Infection Management 2015 (All Rights Reserved)

Questions Do you agree with the duration of the treatment? What general comments would you like to make regarding this case? How might your clinical practice be influenced as a result of this case? © Academy Of Infection Management 2015 (All Rights Reserved)

Comments The infection was most likely due to the K. pneumoniae (in blood and respiratory secretions) The organism probably developed resistance to the empiric therapy The MRSA was likely to be a colonising organism No antibiotic therapy was given specifically to treat infection with MRSA © Academy Of Infection Management 2015 (All Rights Reserved)