The Role of Systemic Retinoids in the Treatment of Cutaneous T-Cell Lymphoma  Auris O. Huen, PharmD, MD, Ellen J. Kim, MD  Dermatologic Clinics  Volume 33, Issue 4, Pages 715-729 (October 2015) DOI: 10.1016/j.det.2015.05.007 Copyright © 2016 The Authors Terms and Conditions

Fig. 1 Retinoid receptor responses. (1) RXR forms homodimers with itself, and with ligand binding, leads to activation of transcription. (2) RXR also forms permissive heterodimers with other nuclear receptors, such as PPAR and LXR-activation of transcription occurs with binding of ligand to either receptor. (3) RXR forms nonpermissive heterodimers with RAR, TR, or VDR. Activation of transcription occurs only with ligand binding on both receptors. DR elements, direct repeat elements; TR, Thyroid hormone receptor; VDR, vitamin D3 receptor. a Ligand. Dermatologic Clinics 2015 33, 715-729DOI: (10.1016/j.det.2015.05.007) Copyright © 2016 The Authors Terms and Conditions

Fig. 2 Recommendations for monitoring patients on systemic retinoids. Dermatologic Clinics 2015 33, 715-729DOI: (10.1016/j.det.2015.05.007) Copyright © 2016 The Authors Terms and Conditions