Live Tweet: #LHSCollaboratory University of Michigan Learning Health System (LHS) Collaboratory Seminar Series WELCOME! Welcome slide – showing as people are entering the room/eating Live Tweet: #LHSCollaboratory

Welcome Dr. Chuck Friedman Agenda Review LHS Collaboratory Workgroup Updates Introduction to the Knowledge Grid Knowledge Grid: Infrastructure to support Knowledge FAIRness for the LHS

Agenda Agenda review Welcome and Introduce Dr. Hu for opening remarks

LHS Collaboratory Workgroups Activity: Combined Workgroup Co-Chair Meeting – May 30, 2017 Initial participant workgroup meetings – June-July, 2017 LHS Collaboratory Workgroup Panel – June 13, 2017 Activity occurring now - June

LHS Collaboratory Workgroups Co-Chair First Meeting Sociotechnical Infrastructure Mark Ackerman Mike Klinkman 6/20/17 9:30-10:30 a.m. THSL 6000 Ethical, Legal and Social Policy Jody Platt Sharon Kardia 6/16/17 10:00-11:00 a.m. THSL 2901 Large Scale Funding Chuck Friedman Doug Van Houweling 6/20/17 2:00-3:00 p.m. VV, Room 204 Organizations and Business Models Jim Woolliscroft Erik Gordon 7/18/17 Time: TBD Location: TBD Implementation and Process Peter Polverini Jack Billi 6/26/17 9:00-10:00 a.m. BSRB, Seminar A All workgroup co-chairs in place; first meetings

The LHS Connects Discovery to Practice Better Health = D2K + K2P + P2D

Infrastructure! Virtuous cycles enable learning but do not create a Learning Health System If you want to get 350,000 people per day across a river, do you build 350,000 rowboats? No, you build a:

A Cyber-Social Platform Supporting Multiple Simultaneous Learning Cycles

Why a Platform? Without a platform: With a platform: Every cycle requires its own agreements, technology, staffing, analytics, dissemination mechanisms No economy of scale Cost of 100 cycles = 100 x (Cost of one) With a platform: All cycles are supported by the infrastructure Big economy of scale Cost of 100 cycles << 100 x

Knowledge Grid: Infrastructure to support Knowledge FAIRness for the LHS Allen Flynn, PharmD Research Analyst Department of Learning Health Sciences