Use of hyperbaric oxygen therapy and PEGylated carboxyhemoglobin bovine in a Jehovah’s Witness with life-threatening anemia following postpartum hemorrhage

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Presentation transcript:

Use of hyperbaric oxygen therapy and PEGylated carboxyhemoglobin bovine in a Jehovah’s Witness with life-threatening anemia following postpartum hemorrhage K. Thenuwara, J. Thomas, M. Ibsen, U. Ituk, K. Choi, E. Nickel, M.J. Goodheart International Journal of Obstetric Anesthesia Volume 29, Pages 73-80 (February 2017) DOI: 10.1016/j.ijoa.2016.10.006 Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 1 Time line of patient’s hemoglobin. POD: postoperative day; Hb: hemoglobin International Journal of Obstetric Anesthesia 2017 29, 73-80DOI: (10.1016/j.ijoa.2016.10.006) Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 2 Diagramatic representation of the three functional units of Sanguinate™, and their properties. Hb: hemoglobin; P50: partial pressure in blood when hemglobin is 50% saturated; PEG:polyethylene glycol; NO nitric oxide International Journal of Obstetric Anesthesia 2017 29, 73-80DOI: (10.1016/j.ijoa.2016.10.006) Copyright © 2016 Elsevier Ltd Terms and Conditions

Fig. 3 Process for obtaining investigational medication in USA via emergency expanded access of a new investigational agent for a single patient use application. Emergency use of an investigational new drug (eIND) outside of clinical trials to treat patients with serious disease for which there are no other therapeutic options. FDA: Food & Drug Administration (responsible for regulating the use of prescription medications and biologicals); IRB: Institutional Review Board (oversees the safe and ethical conduct of research to ensure the well-being of research participants) International Journal of Obstetric Anesthesia 2017 29, 73-80DOI: (10.1016/j.ijoa.2016.10.006) Copyright © 2016 Elsevier Ltd Terms and Conditions