From: Treatment of Excessive Bleeding in Jehovah's Witness Patients after Cardiac Surgery with Recombinant Factor VIIa (NovoSeven®) Anesthes. 2003;98(6):1513-1515.

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From: Treatment of Excessive Bleeding in Jehovah's Witness Patients after Cardiac Surgery with Recombinant Factor VIIa (NovoSeven®) Anesthes. 2003;98(6):1513-1515. Figure Legend: , hemophilia) by directly activating factor X and IX in the presence of tissue factor (TF). Activated factor X (Xa) complexes with factor Va on TF-bearing cells to convert prothrombin (II) to thrombin (IIa). Thrombin formation leads to fibrin formation, platelet activation, activation of fibrin-stabilizing factor (XIII), and thrombin-activatable fibrinolytic inhibitor (TAFI). Date of download: 9/25/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.