HIV/AIDS Implementation Science Research Across NIH: Recent Highlights, Current Priorities, and Partners Christopher Gordon, PhD Branch Chief, Division of AIDS Research National Institute of Mental Health

Top Line Messages HIV/AIDS implementation science has been supported across NIH since prevention and treatment tools have been available A wide range of dissemination and implementation research has been solicited through FOAs from many ICs. Partnering with implementing agencies (e.g., CDC, PEPFAR) has been critical, and continues to expand. Moving forward, important to triage and target highest priorities, coordinate efforts, and seek efficiencies

Implementation Research: What is it?

The Case for Implementation Research in HIV/AIDS Fauci, A. S., et al. (2013). Nature immunology, 14(11), 1104-1107. doi: 10.1038/ni.2735

National Institutes of Health: HIV Implementation Science Elias Zerhouni, M.D. Director, NIH National Institute on Alcohol Abuse and Alcoholism of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute of Diabetes and Digestive and Kidney Diseases of Dental and Craniofacial Research on Drug Abuse of Environmental Health Sciences on Aging of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Eye National Human Genome Research National Heart, Lung, and Blood of Mental Health of Neurological Disorders and Stroke of General Medical Sciences of Nursing Research National Library of Medicine Center for Information Technology Scientific Review National Center for Complementary and Alternative Medicine of Allergy and Infectious Diseases for Research Resources Clinical Center National Center on Minority Health and Health Disparities National Institute of Biomedical Imaging and Bioengineering Fogarty International Center

A (partial) Timeline for NIH-funded HIV/AIDS Implementation Science Early 2000s, research funded in dissemination and implementation science focused on evidence-based prevention interventions NIMH published a PA in 2006 focused on D&I research in collaboration with the CDC’s DEBI project (Diffusion of Effective Behavioral Intervention) NIMH standing FOA (revised and updated every three years) that has evolved with the availability of further prevention and treatment advances. Trans-NIH Implementation Science Workgroup, led by NCI 2009 OAR and Pangaea Global AIDS Foundation Consultation on Implementation Science at IAS, Capetown. PEPFAR workgroup, led by Melanie Bacon (NIAID), including initiatives in implementation science and most recently, in HOP process NIH/PEPFAR RFAs and PAs, starting in 2011, NIAID-led. NIDA/PEPFAR RFA in 2012 NICHD/PEPFAR RFA in 2012 for PMTCT Implementation Science

A (partial) Timeline for NIH-funded HIV/AIDS Implementation Science CFAR, CDC, and Public Health Department collaboration on research efforts to leverage and support the ECHPP efforts (2013-2016) NIMH/NIAID 2013 priority-setting meeting NIMH 2016 supplements “HIV Pre-exposure Prophylaxis (PrEP) Implementation Science in CDC-funded Public Health Demonstration Projects (Admin Supp)” PA-16-199 NIMH standing FOA revised and published in January 2017: “Targeted Implementation Science to Achieve 90/90/90 Goals for HIV/AIDS Prevention and Treatment (R01)” NIMH Initiatives with PEPFAR for PrEP Implementation Science and Mental Health Screening and Treatment in HIV/AIDS Care Settings

Treat All: Policy uptake to full implementation, July 2016 Implementation Science to test models for differentiated care and task-shifting Implementation of Treat All is just starting.

Ambassador Birx: Closing the implementation gap at the Adherence Conference, May 2016   IAPAC Adherence 2017 June 4-6, 2017 • Miami http://www.iapac.org/AdherenceConference/Adherence_2016.html

NIMH-funded projects at PEPFAR sites 28 Active Grants Kenya, Uganda, South Africa, Tanzania, Zambia, Botswana, Mozambique Understanding mobility and risk in SEARCH communities Agricultural Intervention for Food Security and HIV Health Outcomes Real World Adherence to HIV PrEP in Serodiscorant African Couples Activating Treatment as Prevention through Community Mobilization Group Psychotherapy for HIV-Positive Depressed Perinatal Women Patient-Centered Disclosure Intervention for HIV-Infected Children Adaptive Strategies for Preventing & Treating Lapses of Retention in Care CHW's mHealth, and Combination HIV Prevention in a Hotspot

HIV Prevention and Care Continuum, Psychosocial Comorbidities, & Translational Research Branch Chris Gordon Ph.D. Branch Chief; HIV Prevention and Treatment Implementation Science Program Mike Stirratt Ph.D. Adherence to Treatment and Prevention Program Greg Greenwood Ph.D. HIV Testing and Social Determinants Program Teri Senn Ph.D. Psychosocial Co-morbidities of HIV Prevention and Treatment Program

NIMH Funding Opportunities FOAs outline and describe the high priority areas for the DAR programs

Christopher Gordon, Ph.D. NIMH Division of AIDS Research Contact Information Susannah Allison, Ph.D. allisonsu@mail.nih.gov Pim Brouwers Ph.D. ebrouwer@mail.nih.gov Deborah Colosi, Ph.D. Deborah.colosi@nih.gov Christopher Gordon, Ph.D. cgordon1@mail.nih.gov Gregory Greenwood, Ph.D. gregory.greenwood@nih.gov Jeymohan Joseph, Ph.D. jjeymoha@mail.nih.gov Vasudev R Rao, MBBS, MS. raovr@nih.gov Dianne Rausch, Ph.D. drausch@mail.nih.gov Teri Senn, Ph.D. teri.senn@nih.gov Michael Stirratt, Ph.D. stirrattm@mail.nih.gov David Stoff, Ph.D. dstoff@mail.nih.gov 5601 Fishers Lane Rockville, MD 20852 FIX THANKS!