Hypothyroidism. A. Primary hypothyroidism results from failure of the thyroid gland and causes low plasma thyroid hormone levels. There is loss of negative.

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Hypothyroidism. A. Primary hypothyroidism results from failure of the thyroid gland and causes low plasma thyroid hormone levels. There is loss of negative feedback on thyrotropin-releasing hormone (TRH) and thyroid-stimulating hormone (TSH) secretion. B. Secondary hypothyroidism results from the failure of the anterior pituitary to secrete TSH and causes a lack of stimulation of thyroid hormone secretion. High TRH levels result from loss of negative feedback on the hypothalamus. T3, triiodothyronine; T4, thyroxine. Source: Endocrine Physiology, Medical Physiology: The Big Picture Citation: Kibble JD, Halsey CR. Medical Physiology: The Big Picture; 2015 Available at: http://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/Books/1291/p9780071485678-ch008_f016.png&sec=75577821&BookID=1291&ChapterSecID=75577697&imagename= Accessed: September 25, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved