Maternal gestational vitamin D supplementation and offspring bone health (MAVIDOS): a multicentre, double-blind, randomised placebo-controlled trial

Slides:

Advertisements

Similar presentations

Bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1 infection (GS-US ):

Advertisements

Volume 367, Issue 9517, Pages (April 2006)

Volume 1, Issue 7, Pages (December 2014)

Kerry-Anne Rye, Kwok Leung Ong The Lancet Diabetes & Endocrinology

Volume 388, Issue 10042, Pages (July 2016)

Volume 2, Issue 1, Pages (January 2015)

Volume 14, Issue 10, Pages (September 2013)

Volume 386, Issue 10008, Pages (November 2015)

Socioeconomic inequality in neonatal mortality in countries of low and middle income: a multicountry analysis Britt McKinnon, MSc, Sam Harper, PhD, Prof.

Volume 379, Issue 9824, Pages (April 2012)

Depression and violence: a Swedish population study

Maternal gestational vitamin D supplementation and offspring bone health (MAVIDOS): a multicentre, double-blind, randomised placebo-controlled trial

Self-assessment of the outcome of early medical abortion versus clinic follow-up in India: a randomised, controlled, non-inferiority trial Dr Kirti Iyengar,

Effect of a lifestyle intervention on weight change in south Asian individuals in the UK at high risk of type 2 diabetes: a family-cluster randomised.

Volume 383, Issue 9919, Pages (March 2014)

Volume 371, Issue 9611, Pages (February 2008)

Volume 387, Issue 10033, Pages (May 2016)

Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data David A Jolliffe, PhD,

Volume 14, Issue 4, Pages (April 2015)

Volume 383, Issue 9919, Pages (March 2014)

Volume 389, Issue 10071, Pages (February 2017)

Volume 373, Issue 9663, Pages (February 2009)

Volume 392, Issue 10147, Pages (August 2018)

Incidence of type 2 diabetes after bariatric surgery: population-based matched cohort study Helen Booth, MSc, Omar Khan, FRCS, Prof Toby Prevost, PhD,

Effects of a parenting intervention to address maternal psychological wellbeing and child development and growth in rural Uganda: a community-based, cluster-randomised.

Volume 3, Issue 2, Pages (February 2016)

Volume 15, Issue 2, Pages (February 2016)

Volume 382, Issue 9907, Pages (November 2013)

Self-assessment of the outcome of early medical abortion versus clinic follow-up in India: a randomised, controlled, non-inferiority trial Dr Kirti Iyengar,

Montelukast for postinfectious cough in adults: a double-blind randomised placebo- controlled trial Dr Kay Wang, DPhil, Surinder S Birring, MD, Kathryn.

Volume 2, Issue 1, Pages (January 2015)

Volume 381, Issue 9884, Pages (June 2013)

Volume 389, Issue 10077, Pages (April 2017)

Volume 385, Issue 9975, Pages (April 2015)

Effect of nicotine patches in pregnancy on infant and maternal outcomes at 2 years: follow-up from the randomised, double-blind, placebo-controlled SNAP.

Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group,

Volume 387, Issue 10033, Pages (May 2016)

Volume 382, Issue 9900, Pages (October 2013)

Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study Zheng Ye, PhD, Stephen J Sharp, MSc,

Kerry-Anne Rye, Kwok Leung Ong The Lancet Diabetes & Endocrinology

Volume 387, Issue 10023, Pages (March 2016)

Effect of antenatal multiple micronutrient supplementation on anthropometry and blood pressure in mid-childhood in Nepal: follow-up of a double-blind.

Socioeconomic inequality in neonatal mortality in countries of low and middle income: a multicountry analysis Britt McKinnon, MSc, Sam Harper, PhD, Prof.

Volume 15, Issue 10, Pages (September 2014)

Volume 386, Issue 10008, Pages (November 2015)

Volume 15, Issue 12, Pages (November 2014)

Pre-entry screening programmes for tuberculosis in migrants to low-incidence countries: a systematic review and meta-analysis Dr Robert W Aldridge, MSc,

Volume 388, Issue 10042, Pages (July 2016)

Volume 3, Issue 6, Pages (June 2016)

Volume 386, Issue 9998, Pages (September 2015)

Volume 16, Issue 15, Pages (November 2015)

Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial Carolyn Chiswick,

Volume 383, Issue 9922, Pages (March 2014)

Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data David A Jolliffe, PhD,

Volume 15, Issue 13, Pages (December 2014)

Postnatal growth standards for preterm infants: the Preterm Postnatal Follow-up Study of the INTERGROWTH-21st Project Prof José Villar, MD, Francesca.

Volume 16, Issue 15, Pages (November 2015)

Neuromuscular electrical stimulation to improve exercise capacity in patients with severe COPD: a randomised double-blind, placebo-controlled trial Dr.

Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial Prof Lucilla Poston, PhD,

Internet-based intervention for smoking cessation (StopAdvisor) in people with low and high socioeconomic status: a randomised controlled trial Dr Jamie.

Volume 384, Issue 9957, Pages (November 2014)

Volume 375, Issue 9714, Pages (February 2010)

Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis M. Abdin-Mohamed, M.B.B.S., M.R.C.P.,

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial Dr David Preiss, PhD, Suzanne M Lloyd,

Maternal sildenafil for severe fetal growth restriction (STRIDER): a multicentre, randomised, placebo-controlled, double-blind trial Andrew Sharp, PhD,

Anaesthesia-related maternal mortality in low-income and middle-income countries: a systematic review and meta-analysis Soha Sobhy, MBBS, Prof Javier.

Volume 387, Issue 10029, Pages (April 2016)

Volume 373, Issue 9680, Pages (June 2009)

Volume 371, Issue 9611, Pages (February 2008)

Volume 1, Issue 7, Pages (December 2014)

Presentation transcript:

Maternal gestational vitamin D supplementation and offspring bone health (MAVIDOS): a multicentre, double-blind, randomised placebo-controlled trial Prof Cyrus Cooper, FMedSci, Prof Nicholas C Harvey, PhD, Prof Nicholas J Bishop, MD, Prof Stephen Kennedy, MBBS, Prof Aris T Papageorghiou, MD, Inez Schoenmakers, PhD, Robert Fraser, MD, Saurabh V Gandhi, MRCOG, Prof Andrew Carr, DSc, Stefania D'Angelo, MSc, Sarah R Crozier, PhD, Rebecca J Moon, BM, Prof Nigel K Arden, MD, Prof Elaine M Dennison, PhD, Prof Keith M Godfrey, PhD, Prof Hazel M Inskip, PhD, Ann Prentice, PhD, Prof M Zulf Mughal, FRCPCH, Prof Richard Eastell, MD, Prof David M Reid, MD, M Kassim Javaid, PhD The Lancet Diabetes & Endocrinology Volume 4, Issue 5, Pages 393-402 (May 2016) DOI: 10.1016/S2213-8587(16)00044-9 Copyright © 2016 Cooper et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Trial profile 25(OH)D=25-hydroxyvitamin D. DXA=dual-energy x-ray absorptiometry. *Assessments could be done in both the whole body and spine within the same neonate. The Lancet Diabetes & Endocrinology 2016 4, 393-402DOI: (10.1016/S2213-8587(16)00044-9) Copyright © 2016 Cooper et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Neonatal whole-body bone mineral content (A), bone area (B), and bone mineral density (C) by intervention group and season of birth Data shown are mean and 95% CI. Winter is December to February, spring is March to May, summer is June to August, and autumn is September to November. BMC=bone mineral content. BMD=bone mineral density. The Lancet Diabetes & Endocrinology 2016 4, 393-402DOI: (10.1016/S2213-8587(16)00044-9) Copyright © 2016 Cooper et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 3 Maternal 25(OH)D status at baseline (14 weeks' gestation) and 34 weeks' gestation by intervention group and season of birth Data shown are mean and 95% CI. Winter is December to February, spring is March to May, summer is June to August, and autumn is September to November. 25(OH)D=25-hydroxyvitamin D. The Lancet Diabetes & Endocrinology 2016 4, 393-402DOI: (10.1016/S2213-8587(16)00044-9) Copyright © 2016 Cooper et al. Open Access article distributed under the terms of CC BY Terms and Conditions