TriCurin TM - a novel therapeutic for human papillomavirus infection ™ TriCurin TM - a novel therapeutic for human papillomavirus infection Fighting HPV - Synergy of Science & Nature's Evolution Co-founder & President Mario Castellanos, MD

Human Papillomavirus Infection is a Growing Epidemic, Yet Lacks Treatment Options 700,000 Chronic HPV Infections 270,000 precancers 10,000 cancers US Annual Figures Cervical HPV (+) Disease - 14 Million new HPV infections a year (US) 2nd most common STD -10 % HPV infections become persistent, drive malignancies - $4 billion spent in diagnosis and treatment - No antivirals to prevent cancer - Multiple Billion Dollar market opportunity InnoveneMeds.com 2 InnoveneMeds.com 2 2

TriCurin™ is a Targeted Therapy to Cure HPV Infection Tricurin is a novel formulation of 3 plant compounds that directly block HPV replication Induce apoptosis in HPV-infected lesions Spare normal tissue Inhibition of HPV E6 & E7 proteins Essential for viral replication Abnormal levels induce cancer Lead Indication Treatment of chronic cervical HPV infection Cream for self administration, easy to use Protected by global patent estate E6 & E7 E4 L1 & L2 E1, E2 & E5 HPV Squamous Epithelium Basement Membrane Mukherjee S, et al. Oncotarget 2017 In Press. Debata PR, et al Gynecol Oncol 2013;129(1):145-53 InnoveneMeds.com 3 3 3

Phase I Proof of Concept Design Clinical Trials Phase I clinical trial Women with chronic cervical HPV infection Primary endpoint: Safety and tolerability Secondary: Clinical efficacy (viral load, biomarkers) Clinical site: Northwell Health Time to completion: 1 year Established Phase 2 & 3 trials Post Phase I: Typical development programs for NDA submission (time 4 years) Potential launch : 4-5 years post Phase I trial IND Phase 1 Trial Phase 2 Trial Phase 3 Trial FDA InnoveneMeds.com 4

Management Team Co-Founder & Director, Business Development Alia Kozlova, PhD Richmond Green, DOO, Co-founder Head of Strategy & Planning, BAT, Regional and Area level General Manager Russia & CIS, Middle East Marketing Research Bureau Director, Clinical Program Anita Szerszen, DO IRB Chair, Northwell Health Research Director, Geriatrics Division Northwell Health, Staten Island Co-Founder & President Mario Castellanos, MD Director Medical Women’s Health Clinical Director Research, Northwell Health Department of Medicine, Staten Island Chief Executive Officer Mike Wassil, CPA Experienced C-Level Executive 30 years of experience Participated in over 50 M&A, Managed two IPO’s InnoveneMeds.com 5 5

Job Description - Clinical Project Manager Strategically thinking, highly motivated person to join our team... Summary Assist to acquire the IND and implement the start of the Phase I clinical trial Key Knowledge & Skills Science and/Clinical degree (PhD, MD, MS, RN, or MPH) Excellent interpersonal and communication skills (verbal and written) Strong organizational and time management skills Self-motivation and attention to detail Responsibilities & Duties 1) Working with Academic &industry laboratories consultants and CRO’s Innovene ‘s Business and Clinical team 2) Assist in writing sections of the IND 3) Develop SOP’s 4) Interact with Clinical site & investigators InnoveneMeds.com 6 6

Thank Y u Contact Mario@InnoveneMeds.com 718-809-2183 www.InnoveneMeds.com