Predictors of survival in restrictive chronic lung allograft dysfunction after lung transplantation Stijn E. Verleden, PhD, David Ruttens, MD, Elly Vandermeulen,

Slides:

Advertisements

Similar presentations

Systolic blood pressure on discharge after left ventricular assist device insertion is associated with subsequent stroke Michael E. Nassif, MD, Anjan Tibrewala,

Advertisements

Sixth INTERMACS annual report: A 10,000-patient database James K. Kirklin, MD, David C. Naftel, PhD, Francis D. Pagani, MD, PhD, Robert L. Kormos, MD,

Janet T. Lee, MD, Rosemary F. Kelly, MD, Marshall I

The Registry of the International Society for Heart and Lung Transplantation: Thirty- second Official Adult Lung and Heart-Lung Transplantation Report—2015;

Debapriya Datta, MD, FCCP, Vanessa Yap, MD CHEST

Evan P. Kransdorf, MD, PhD, Michelle M. Kittleson, MD, PhD, Jignesh K

The utility of 6-minute walk distance in predicting waitlist mortality for lung transplant candidates Anthony Castleberry, MD, MMCI, Michael S. Mulvihill,

Patterns and Predictors of Physical Functional Disability at 5 to 10 Years After Heart Transplantation Kathleen L. Grady, PhD, RN, David C. Naftel, PhD,

Chest X-ray Screening Improves Outcome in Lung Cancer

De novo donor-specific HLA antibodies are associated with early and high-grade bronchiolitis obliterans syndrome and death after lung transplantation

Volume 74, Issue 5, Pages (November 1978)

Cavitary Lung Lesion in a Patient With Congestive Heart Failure

Kazuma Nagata, MD, Reiko Kaji, MD, Keisuke Tomii, MD

Incremental and independent value of cardiopulmonary exercise test measures and the Seattle Heart Failure Model for prediction of risk in patients with.

Can the Seattle Heart Failure Model Be Used to Risk-stratify Heart Failure Patients for Potential Left Ventricular Assist Device Therapy? Wayne C. Levy,

Volume 139, Issue 4, Pages (April 2011)

Volume 101, Issue 2, Pages (February 1992)

Volume 102, Issue 6, Pages (December 1992)

Impact of initial Norwood shunt type on young hypoplastic left heart syndrome patients listed for heart transplant: A multi-institutional study Waldemar.

Low vitamin D levels are associated with increased rejection and infections after lung transplantation Erin M. Lowery, MD, Bradford Bemiss, MD, Thomas.

Volume 142, Issue 2, Pages (August 2012)

Utility of Pneumonotomy in the Treatment of Cavitary Lung Disease

Limitations of right heart catheterization in the diagnosis and risk stratification of patients with pulmonary hypertension related to left heart disease:

Pre-operative mortality risk assessment in patients with continuous-flow left ventricular assist devices: Application of the HeartMate II risk score

Chronic Skin Eruptions Preceding a Cavitating Lung Lesion

Outcomes in highly sensitized pediatric heart transplant patients using current management strategies Alfred Asante-Korang, MD, Ernest K. Amankwah, PhD,

Two decades of pediatric lung transplant in the United States: Have we improved? Farhan Zafar, MD, Jeffrey S. Heinle, MD, Marc G. Schecter, MD, Joseph.

A 51-Year-Old Woman With an Increasing Chest Wall Mass Years After Resection of an Early Stage Lung Cancer Ajay Dhakal, MBBS, Hongbin Chen, MD, PhD,

Liver Metastasis Is Associated with Poor Progression-Free Survival in Patients with Non–Small Cell Lung Cancer Treated with Nivolumab Tomoko Funazo,

Extracorporeal membrane oxygenation as a bridge to lung transplantation is about more than just surviving Dirk Van Raemdonck, MD, PhD, Fabienne Dobbels,

Does the method of lung preservation influence outcome after transplantation? An analysis of 681 consecutive procedures J. Saravana Ganesh, FRCS, Chris.

Pulmonary Infiltrates and Eosinophilia Associated With Sulfasalazine

Incidence and Survival of Malignant Pleural Mesothelioma in Norway: A Population- Based Study of 1686 Cases Åslaug Helland, MD, PhD, Steinar Solberg,

Early readmission for congestive heart failure predicts late mortality after cardiac surgery Richard Lee, MD, MBA, Natalie Homer, BS, Adin-Cristian Andrei,

Toronto bridges to successful lung transplantation

Debapriya Datta, MD, FCCP, Vanessa Yap, MD CHEST

Prognostic Factors in Completely Resected Node-Negative Lung Adenocarcinoma of 3 cm or Smaller Jung-Jyh Hung, MD, PhD, Yi-Chen Yeh, MD, Yu-Chung Wu,

Volume 135, Issue 5, Pages (May 2009)

Successful Treatment with Erlotinib after Gefitinib-Induced Severe Interstitial Lung Disease Masayuki Takeda, MD, PhD, Isamu Okamoto, MD, PhD, Chihiro.

Esophageal Ultrasound-Controlled Fine Needle Aspiration for Staging of Mediastinal Lymph Nodes in Patients with Resectable Lung Cancer: Do We Always See.

Cytomegalovirus Infection after Allogeneic Transplantation: Comparison of Cord Blood with Peripheral Blood and Marrow Graft Sources Christopher M. Walker,

Liver Metastasis Is Associated with Poor Progression-Free Survival in Patients with Non–Small Cell Lung Cancer Treated with Nivolumab Tomoko Funazo,

Metastasectomy in a lung graft using high-flow venovenous extracorporeal lung support in a patient after single lung transplantation Bassam Redwan, MD,

Volume 138, Issue 4, Pages (October 2010)

Jeffrey T. Yorio, MD, Yang Xie, PhD, Jingsheng Yan, PhD, David E

Living by numbers The Journal of Thoracic and Cardiovascular Surgery

Outcomes of Delayed Chest Closure After Bilateral Lung Transplantation

Chronic Stenotrophomonas maltophilia infection and mortality or lung transplantation in cystic fibrosis patients Valerie Waters, Eshetu G. Atenafu, Annie.

Is it really dumb to leave a stump?

The influence of retransplantation on survival for pediatric lung transplant recipients Ryuichi Waseda, MD, PhD, Alberto Benazzo, MD, Konrad Hoetzenecker,

Pulmonary Infiltrate with Eosinophilia

Volume 83, Issue 5, Pages (May 2013)

Diabetes mellitus and survival in cystic fibrosis patients after lung transplantation Markus Hofer, Christoph Schmid, Christian Benden, Rudolf Speich,

A 54-Year-Old Man Referred With Nonresolving Pneumonia

T4 or MI? Journal of Thoracic Oncology Volume 6, Issue 3, (March 2011)

Pretransplant Panel Reactive Antibodies in Human Lung Transplantation: An Analysis of Over 10,000 Patients Ashish S. Shah, MD, Lois Nwakanma, MD, Christopher.

Sophie F. Demarche, MPharm, Florence N. Schleich, MD, PhD, Virginie A

Survival after Trimodality Treatment for Superior Sulcus and Central T4 Non-small Cell Lung Cancer Paul De Leyn, MD, PhD, Johan Vansteenkiste, MD, PhD,

COUNTERPOINT: Does Interstitial Pneumonia With Autoimmune Features Represent a Distinct Class of Patients With Idiopathic Interstitial Pneumonia? No

Metastatic Lung Cancer to the Pancreas

Volume 108, Issue 5, Pages (November 1995)

Jeffrey H. Shuhaiber, MD, Jeff Moore, MS, David B. Dyke, MD

Treatment versus Transplant for Challenging Hematologic Disorders

David Garfield, MD Journal of Thoracic Oncology

John Reid, MD, Donald Cockcroft, MD CHEST

Post-pneumonectomy Pericardial Effusion

Popcorn in the Lung Journal of Thoracic Oncology

Nutrition During Trimodality Treatment in Stage III Non-small Cell Lung Cancer: Not Only Important for Underweight Patients Barbara S. van der Meij,

Commentary: Evaluation of primary graft dysfunction after lung transplantation—It is time to teach an old dog new tricks! W. Hampton Gray, MD, P. Michael.

Risk factors for primary graft dysfunction after lung transplantation

Presentation transcript:

Predictors of survival in restrictive chronic lung allograft dysfunction after lung transplantation Stijn E. Verleden, PhD, David Ruttens, MD, Elly Vandermeulen, Ir, Hannelore Bellon, Ir, Adriana Dubbeldam, MD, Walter De Wever, MD, PhD, Lieven J. Dupont, MD, PhD, Dirk E. Van Raemdonck, MD, PhD, Bart M. Vanaudenaerde, PhD, Geert M. Verleden, MD, PhD, Christian Benden, MD, FCCP, Robin Vos, MD, PhD The Journal of Heart and Lung Transplantation Volume 35, Issue 9, Pages 1078-1084 (September 2016) DOI: 10.1016/j.healun.2016.03.022 Copyright © 2016 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 1 Graft loss in patients diagnosed with rCLAD for the Zurich, Leuven and total cohorts. Median time to graft loss was 1.1 years in the total cohort. One-, 3- and 5-year survival was 55%, 24% and 6%, respectively. The Journal of Heart and Lung Transplantation 2016 35, 1078-1084DOI: (10.1016/j.healun.2016.03.022) Copyright © 2016 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 2 (A) Graft loss in patients diagnosed with rCLAD sub-divided based on the localization of CT infiltrates at the moment of rCLAD diagnosis. Better survival was observed in patients with upper lobe infiltrates compared with diffuse or lower lobe infiltrates (p = 0.0021). Median survival was 2.2 years, 0.6 year and 0.3 year for apical, basal and diffuse presence of CT infiltrates, respectively. (B) Representative example of high-resolution CT (HRCT) chest scan with upper lobe predominant infiltrates. (C) Example of HRCT scan with diffuse infiltrates. (D) Representative example of HRCT scan with lower lobe predominance. The Journal of Heart and Lung Transplantation 2016 35, 1078-1084DOI: (10.1016/j.healun.2016.03.022) Copyright © 2016 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 3 (A) ROC curve for 1-year mortality after rCLAD diagnosis based on absolute blood eosinophil count. Absolute blood eosinophilia was a good predictor of 1-year mortality (p = 0.0001, area under the curve = 0.80). Blood eosinophilia >240 × 106/liter had 71% sensitivity and 86% specificity to predict 1-year survival. (B) Log-rank comparison of patients with absolute eosinophil count >240 × 106/liter and ≤240 × 106/liter. The Journal of Heart and Lung Transplantation 2016 35, 1078-1084DOI: (10.1016/j.healun.2016.03.022) Copyright © 2016 International Society for Heart and Lung Transplantation Terms and Conditions