Endometriosis: A Woman’s Struggle

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Presentation transcript:

Endometriosis: A Woman’s Struggle Nicole Li| Professor Jim Dixon | Biological Research 2017

What is endometriosis? Displaced endometrial tissue causes Scar tissue Adhesions Cysts (endometriomas)

Symptoms “Killer” cramps Pain with bowel movements, urination, etc Fatigue Constipation Bloating and nausea Infertility Higher risk of ovarian cancer and endometriosis-associated adenocarcinoma

Current Treatment & (Limited) Diagnosis Methods Hormone therapy Danazol Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists Surgery Conservative Hysterectomy Pelvic exams- not possible to feel small areas of endometriosis, unless they've caused a cyst to form Ultrasounds- cysts only Laparoscopy- assumes that endometriotic lesions will always be visible when in fact endometriosis can exist microscopically and still cause pain

Some Little Problems Not everyone can tolerate something. Nothing is effective for everyone. Not everything is available to everyone. Not everything is what it seems.

SynBio Approaches Disrupted Hormone Sensing Unique miRNA Profiles

References http://www.mayoclinic.org/diseases-conditions/endometriosis/diagnosis-treatment/treatment/txc- 20236449 https://www.theodysseyonline.com/mit-igem-endometriosis http://2016.igem.org/Team:MIT/Genetic_Circuit https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346178/ https://www.glowm.com/section_view/heading/Genetics%20of%20Endometriosis/item/362#2431 https://thetech.com/2017/07/26/endometriosis-gynepathology