A dog model to study ovary, ovarian ligament and visceral pain

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Presentation transcript:

A dog model to study ovary, ovarian ligament and visceral pain Pedro Boscan, Eric Monnet, Khursheed Mama, David C Twedt, Jonathan Congdon, Jens C Eickhoff, Eugene P Steffey Veterinary Anaesthesia and Analgesia Volume 38, Issue 3, Pages 260-266 (May 2011) DOI: 10.1111/j.1467-2995.2011.00611.x Copyright © 2011 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Terms and Conditions

Figure 1 Procedure diagram. (a): Intra-abdominal view of 2-0 byosin suture penetrating the abdominal wall. The needle is manipulated inside the abdominal cavity with Babcock forceps (b). (b): The suture passes through and around the ovarian ligament (l) and ovary (o). (c): The suture is exteriorized through the abdominal wall for manual stimulation. The stimulus is performed with a calibrated force transducer to quantify the tension used. (d): During stimulation, the suture will pull the ovary and ovarian ligament inducing a visceral response. The uterus (u) moves during stimulation but not enough to induce a noxious response. Veterinary Anaesthesia and Analgesia 2011 38, 260-266DOI: (10.1111/j.1467-2995.2011.00611.x) Copyright © 2011 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Terms and Conditions

Figure 2 Stimulus – response curve. The stimulus – response curve for sevoflurane MAC when different stimulation forces were applied to the right ovary. The mean ± SD of sevoflurane MAC was measured using the end-tidal sevoflurane concentration. The stimulation force was recorded using a force transducer. # indicates MAC values that were different when compared to 1.96 N. The remaining MAC values were not different between them (p > 0.05). Veterinary Anaesthesia and Analgesia 2011 38, 260-266DOI: (10.1111/j.1467-2995.2011.00611.x) Copyright © 2011 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Terms and Conditions

Figure 3 Tail and ovary MAC. Box plot graph indicating and comparing the descriptive statistics between the ovary and tail MAC. The median, 25% and 75% percentile and minimum and maximum values are depicted. Veterinary Anaesthesia and Analgesia 2011 38, 260-266DOI: (10.1111/j.1467-2995.2011.00611.x) Copyright © 2011 Association of Veterinary Anaesthetists and American College of Veterinary Anesthesia and Analgesia. Terms and Conditions