Protein Structure Basics!

Slides:

Advertisements

Similar presentations

Proteins Review. Learning outcomes (e) Describe the structure of an amino acid and the formation and breakage of a peptide bond. (f) Explain the meaning.

Advertisements

Pages 42 to 46.  Chemical composition  Carbon  Hydrogen  Oxygen  Nitrogen  Sulfur (sometimes)  Monomer/Building Block  Amino Acids (20 different.

Proteins & Nucleic Acids Images taken without permission from

1 PROTEINS. 2 Proteins Proteins are polymers made of monomers called amino acids (aka building blocks) 8-10 we can not make. All proteins are made of.

Biology 107 Macromolecules II September 9, Macromolecules II Student Objectives:As a result of this lecture and the assigned reading, you should.

Polypeptides – a quick review A protein is a polymer consisting of several amino acids (a polypeptide) Each protein has a unique 3-D shape or Conformation.

Biology 107 Macromolecules II September 8, 2003.

Proteins Structures Primary Structure.

Daily Starter  Explain how a peptide bond is formed. (What is the reaction called and how does it happen?)

Biomolecules: Nucleic Acids and Proteins

Diverse Macromolecules. V. proteins are macromolecules that are polymers formed from amino acids monomers A. proteins have great structural diversity.

Chapter 3 Protein Structure and Function. Key Concepts Most cell functions depend on proteins. Amino acids are the building blocks of proteins. Amino.

Protein Modeling Lab Things to check before the modeling lab:

1 Proteins AP Biology Proteins Multipurpose molecules.

PROTEINS. Learning Outcomes: B4 - describe the chemical structure of proteins List functions of proteins Draw and describe the structure of an amino acid.

Amino acids and proteins … for AS Biology. Amino acids Proteins are macromolecules consisting of long unbranched chains of amino acids. All amino acids.

Mrs. Einstein Research in Molecular Biology. Importance of proteins for cell function: Proteins are the end product of the central dogma YOU are your.

PROTEINS The final product of the DNA blueprint Hemoglobin.

BIOLOGICALLY IMPORTANT MACROMOLECULES PROTEINS. A very diverse group of macromolecules characterized by their functions: - Catalysts - Structural Support.

Amino Acids & Proteins The Molecules in Cells Ch 3.

Protein Structure and Enzyme Function

Protein Structure Primary - sequence of amino acids Secondary – folding into pleated sheets or alpha helix Tertiary – 3-D structure, completely folded.

Protein- Secondary, Tertiary, and Quaternary Structure.

 Protein structure is complex and can be divided into four levels.  1. Primary structure = the sequence of amino acids in a polypeptide chain ◦ Genes.

Protein Structure  The structure of proteins can be described at 4 levels – primary, secondary, tertiary and quaternary.  Primary structure  The sequence.

Protein Structure. Insulin Infinite variety The number of possible sequences is infinite An average protein has 300 amino acids, At each position there.

PROTEINS Have a wide range of functions; haemoglobin, antibodies & enzymes Amino acids are the monomers Twenty naturally occurring amino acids The order.

Fall OSI Protein Modeling Challenge December 2010.

PROTEINS Proteins Composed mainly of –Carbon –Hydrogen –Nitrogen.

Four Levels of Protein Structure

Empowering Teachers Through Modeling

19.5 Protein Structure: Tertiary and Quaternary Levels

Empowering Teachers Through Modeling

Chapter 5 The Structure and Function of Macromolecules

Amino Acids, Proteins & Enzymes Chapter 16

Protein Proteins are found throughout living organisms.

Structures of Proteins and Denaturation

Protein Structures There are 4 protein structures.

Amino Acids and Proteins

5 E’sy Ways to Investigate enzymes!

Protein Folding.

Keep Your Head Above Water with Magnetic Water Molecule Models

Getting Students Through

Proteins – V2.

Proteins Section 3.4.

Protein Structure and Function

Amino Acids as Protein Building Blocks

Protein Structure and Examples

Macromolecules: Proteins

. Nonpolar (hydrophobic) Nonpolar (hydrophobic) Amino Acid Side Chains

Macromolecules Part 2 Unit 1 Chapter 5.

The Chemistry of Life Proteins

Diverse Macromolecules

Study Question: What are enzymes?

Enzymes and Proteins.

MT 5 Protein Synthesis Simple Detail:

Protein Structure Chapter 14.

Introduction and Fundamentals of Protein Structure

Introduction and Fundamentals of Protein Structure

Protein Structure and Examples

The final product of the DNA blueprint

Four Levels of Protein Structure

Presentation transcript:

Protein Structure Basics! Empowering Teachers Through Modeling Protein Structure Basics!

Learning Objectives Educators attending this workshop will: Utilize tools that support NGSS student learning outcomes of three dimensional lesson design. Molymods Amino Acid Starter Kit© Learn something new and interesting for your own professional development. HAVE FUN!

What NGSS dimensions will be targeted? Learning Objectives What NGSS dimensions will be targeted? SEPs CCCs DCIs Asking questions Patterns PS1.A: Structure and properties of matter Developing and using models Cause and effect PS1.B: Chemical reactions Constructing explanations Scale, proportion, and quantity LS1.A: Structure and function Structure and function LS2.C: Ecosystem dynamics, functioning, and resilience

Protein Structure versus . . . the Mosquito The Phenomenon!

Amino Acids: Building Blocks for Proteins

Amino Acids: D and L Forms of Amino Acids

Amino Acids Exist as Zwitterions!

Amino Acid Form is Dependent on pH!

Building a Dipeptide

Beware student preconceptions about protein folding! The Protein Folding Problem Beware student preconceptions about protein folding! Amino Acid #1 #2

Modeling Protein Structure

Modeling the Primary Structure You will need 15 total side chains: 2 cysteine side chains (green). 2 acidic side chains (red). 2 basic side chains (blue). Your favorite 3 hydrophilic amino acids (white). Your favorite 6 hydrophobic amino acids (yellow). Randomly distribute them on the TOOBER. (Space them about three inches apart to get an even distribution).

Modeling Tertiary Structure Fold your protein according to basic principles of chemistry and physics: In an aqueous environment, where do you expect the hydrophobic side chains to fold? Why? Likewise, where would the hydrophilic side chains occur? What interaction may occur between acidic and basic amino acids? What interaction may occur between cysteine amino acids?

Modeling the Primary Structure Some points to ponder: Why are all of the folded structures in this room different? 2. If an unlimited number of each of the 20 amino acid sidechains were available . . . . How many different sequences of 15 amino acids are possible? 3. It is estimated that there are 100,000 different proteins in the body. If the average protein is about 300 amino acids long, then there are 20300 possibilities! Why are there fewer proteins in the body than possible?

Modeling Secondary Structure Beta Sheets Why are secondary structures important to protein structure/function? Alpha Helices

Modeling Quaternary Structure Hemoglobin