Gene Editing Opportunity for Accelerating Gain

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Presentation transcript:

Gene Editing Opportunity for Accelerating Gain November 2016

Genetic Evolution 10,000 BC 2016

Efficiency & sustainability Genetic Evolution Domestication Selective breeding Directed recombination? 1900 AD 2000 2010 2015 10,000 BC Efficiency & sustainability prolificacy, feed efficiency, health & robustness Meat quality taste, leanness, yield Darwin develops evolution theory MU announces PRRS resistant pig Mendel ‘invents’ genetic science Gene editing ‘invented’ Shull describes heterosis Relationship Based Genomics Watson & Crick describe DNA molecule Cost to sequence drops factor 1000 in 3 years First transgenic Crop introduced Human Genome Project completed

Selective Breeding Works Prolificacy 14 pigs Per year 28 pigs Per year +100% Feed conversion 900 lbs of feed each pig 550 lbs of feed each pig -40% Meat quality 75 lbs of lean each pig 120 lbs of lean each pig +60% Manure reduced per lb of lean meat by more than 60%

Selective Breeding Evolves Progressing from traditional BLUP and single markers to a full description of the genome along with our global phenotype and pedigree database – improving the accuracy of selection 2013 As in 2013 + F1 RBGS*+ Imputation + PIC Customized HD/LD genotypes 2014 RBGS* + 60K HD Multiple markers GS 60K HD 2012 SNP Discovery 2010 2009  2008 *RBGS: Relationship Based Genomic Selection

Utilizing the Best Science Relationship Based Genomic Selection Without genomic data: the “family tree” - Assume relatedness (r) = 50% for all littermates

Utilizing the Best Science Relationship Based Genomic Selection Genotypes determine what proportion the genome animals share

Accelerating Genetic Gain Selective Breeding PIC Full Program 5 Year Avg 3 Year Avg 1 Year Avg Index 12.9 15.8 19.4 Pigs weaned/sow/year 0.9 1.1 Pounds weaned/sow/year 11.9 17.4 Pigs marketed/sow/year Pounds marketed/sow/year 57.2 81.1 126.7 PROFIT PER PIG, $ / pig 2.58 3.16 3.88

What’s Next?

Accelerating Genetic Gain What’s Next?

Accelerating Genetic Gain What’s next? Genome Sequencing Impact Greater selection accuracy Causal variants Capture de-novo mutations Molecular biology targets Likelihood High In-process Timeline 3 years

Accelerating Genetic Gain What’s Next? Gene Editing

The Process

The Next Frontier…

...will bring exciting options...

...will bring exciting options...

...and is really already here.

Delivering Unique Value

PRRS Resistance High Level Overview Pigs were created with minor nucleotide edits within their existing DNA No new or foreign DNA was inserted into the pigs

What’s next? Conduct trials to validate safety & efficacy Collaborate with FDA on regulatory framework Understand and address societal concerns Look ahead: continue innovation to advance animal ag

PIC is dedicated to the responsible exploration of innovations that benefit the well-being of animals, farmers, and society