Duplex Ratio Tests as Diagnostic Biomarkers in Malignant Melanoma

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Presentation transcript:

Duplex Ratio Tests as Diagnostic Biomarkers in Malignant Melanoma David A. Moore, Gerald Saldanha, Abdlrzag Ehdode, Mohamed Z. Mughal, Linda Potter, Lovesh Dyall, James H. Pringle The Journal of Molecular Diagnostics Volume 17, Issue 5, Pages 616-622 (September 2015) DOI: 10.1016/j.jmoldx.2015.05.001 Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

Figure 1 Plot of corrected ΔΔCt (cΔΔCt) values for the seven duplex ratio tests in the comparison of nevi, primary melanomas that had not metastasized (P-M), and primary melanomas that had metastasized (P+M) in the discovery set. The Journal of Molecular Diagnostics 2015 17, 616-622DOI: (10.1016/j.jmoldx.2015.05.001) Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

Figure 2 Receiver operating characteristic (ROC) curve of the specificity and sensitivity of the full panel of duplex ratio tests to differentiate between melanoma and nevi from the 268 cases using the ΔΔCt scores. Area under the curve = 0.933. The Journal of Molecular Diagnostics 2015 17, 616-622DOI: (10.1016/j.jmoldx.2015.05.001) Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions