Vaclav Kirsner, PhD, Founder CEO Transforming Female Reproductive Health Management Vaclav Kirsner, PhD, Founder CEO bioZhena Corporation http://www.biozhena.com/ vaclav@biozhena.com (970) 484-1272 Auguste Rodin, The Kiss Profits from the already FDA-cleared application of the Ovulona™ will support the introduction of the next applications Left click on link to connect. Hover over link to read about it . Return here by closing the window (top) NOT the tab.

Broad electrometric applicability of the Ovulona™ Prolog THIS SLIDE IS WITHOUT MY VOICE & WITHOUT AUTO-ADVANCE. CLICK TO ADVANCE OR USE NAVIGATION BUTTONS (BOTTOM LEFT) Broad electrometric applicability of the Ovulona™ There is solid precedent for observing differences between electrometric* signatures of normal healthy cervical tissues (epithelia) and those of aberrant tissues (e.g. pre-cancerous CIN epithelia) “as significant as those obtained from analyzing Pap smear tests”. *Electrometric refers to electronic measurements. The measured differences as time goes on are due to changes in the external and internal structure of the cervical tissue cells. The same holds for other physiological changes in the tissues - including folliculogenesis and pregnancy. Note these key words in the titles of randomly selected 3 publications: 1. impedance of the cervix in non-pregnant and pregnant women 2. cervical impedance in the prediction of the course and outcome of labor 3. uterine and cervical electromyography in monitoring pregnant patients And note conclusion of publication #3 (re: the future applications of the Ovulona): The potential benefits include… a reduction in the rate of preterm birth, improved maternal and perinatal outcome, better monitoring of treatment… Edit Hyperlink – after you’ve made it Place in this document = slide # Screen Tip – 256 characters max Left click on link to connect. Hover over link to read about it . Return here by closing the window (top) NOT the tab.

What does Ovulona™ do? It tracks folliculogenesis in vivo (FIV™) Folliculogenesis is central to women’s health, well-being, and lifestyle. Tracking its course generates menstrual cycle Vital Sign® signatures for physicians and payers. Women and their health care providers will be offered a new healthcare tool with unprecedented diagnostic capabilities and user friendliness. The Ovulona™ predicts and then detects ovulation through an innocuous biophysical (electrochemical) measurement in the vagina as a way of defining the "fertile window" that is objective, precise, minimally intrusive, and instrument-based. The Ovulona is intended for use at home by any woman of childbearing age. … the Ovulona sensor is in resonance with the electrochemical properties of the exocervix/posterior fornix tissues that yield the diagnostically useful signal-versus-time graph (tissue admittance versus day of cycle). We focus on the signal-versus-time pattern rather than on a visual image of an anatomical component of the studied system. Our optimization of the admittance measurement suppresses the faradaic and bulk conductivity components of the admittance, to make it dependent on the capacitive component. Ovulona™ Personal Fertility Smart Sensor Photo of a rapid prototyping model Note: This is not the real prototype. Real details are not shown. The planned internally worn telemetric cervical ring is not shown either. Left click on link to connect. Hover over link to read about it . Return here by closing the window (top) NOT the tab. 3

What Is Folliculogenesis? The biological foundation of a woman’s well-being.

What Is Folliculogenesis? And What Is Folliculogenesis In Vivo(TM)? Folliculogenesis has been known to biomedical specialists since the late decades of 1900s. It is the process of ovarian function with biologically defined timing of events known as recruitment, selection, dominance and ovulation [G.D.Hodgen, Fertility and Sterility 38:28 1, 1983]. This refers to the formation and maturation of the dominant follicle in the ovary, followed by the follicle rupture and the release of the egg (ovulation); only then, for about 8 to 12 hours, can the egg (or “ovum”) be fertilized. Significantly, too, some other endocrine organs communicate stimulatory and inhibitory signals to the ovary, to which the ovary feeds back its signals. Since in this manner there is a connection between the hypothalamus and the pituitary gland of the brain on the one hand and the two ovaries on the other, this connection is called the Hypothalamic-Pituitary-Ovarian axis or (as in the upper diagram) the Hypothalamus-Pituitary-Gonad Feedback Loop. Our achievement is the In Vivo manner of tracking the process via the outer cervical tissues. We call the technique Folliculogenesis In Vivo(TM). CLICK RIGHT ARROW FOR NEXT SLIDE

Technology Overview Revolutionary technology – FOLLICULOGENESIS IN VIVO™ Generates menstrual cycle Vital Sign® signatures Monitors the cervix – the natural monitor of reproduction Cervical health screened innocuously, at home Designed to improve quality and reduce costs of women’s reproductive and general health - from adolescence to menopause: Help women to conceive & plan baby’s sex Automatic instant detection of pregnancy and of the too frequent Early Pregnancy Loss Forecast Expected Date of Delivery Monitor pregnancy, help manage normal and preterm labor for better outcomes Provide timing tool for natural birth control Help manage other conditions such as: menstrual cramps PMS/PMDD peri-menopause screen for cervical cancer, STDs Left click on link to connect. Hover over link to read about it . Return here by closing the window (top) NOT the tab.

Breakthrough For Trying-To-Conceive Women MOSTLY GIRLS BORN 69% MOSTLY BOYS BORN 77% Male spermatozoa (Y-chromosome-bearing sperm) live longer than female spermatozoa (X-chromosome-bearing sperm) G.D. Hodgen et al., Andrologia 33,199 (2001) FERTILE DAY 1 2 3 J.T. France et al., "Characteristics of natural conception cycles occurring in a prospective study of sex preselection...", Int J Fertility 37 (4), 224 - 255, 1992 Male spermatozoa (Y-chromosome-bearing sperm) live longer than female spermatozoa (X-chromosome-bearing sperm) G.D. Hodgen et al., Andrologia 33,199 (2001) J.T. France et al., "Characteristics of natural conception cycles occurring in a prospective study of sex preselection...", Int J Fertility 37 (4), 224 - 255, 1992 Precise determination of the 3-day fertile window Clear daily indications: FERTILE DAY # or mostly INFERTILE Easy to use Smart Ovulona™ and next generation Halo™ telemetric cervical ring Automatically detects & monitors pregnancy, computes Expected Delivery Date Requires no chemical work, no graphing, no interpretation of data by the user Provides folliculogenesis profile vital sign signature data to physicians and payers Provides innocuous inexpensive built-in screen for cervical cancer, other STDs

Ovulation prediction products From upper left: A digital thermometer; an inexpensive microscope for assessment of the appearance of saliva; the Cue Fertility Monitor from Zetek, with two probes, one for the vagina and the other for the mouth, DuoFertility BBT monitor. From upper right: an LH kit with sample of colors between which the user must decide; and the Clearblue Fertility Monitor that performs the color assessment electronically. A very expensive IT adaptation of the old BBT technique that does not (cannot) anticipate ovulation. Their counselors help infertility sufferers to practice “focused intercourse” aiming to avoid or at least minimize the high costs of Artificial Reproductive Technologies (ARTs).

The Ovulona provides the best quality, Comparison of technologies in the Trying-To-Conceive self-help market This is Ovulona monitor’s first application, FDA-ready for market Characteristics Ovulona™ BBT Thermo meters LH kits urine chemistry Saliva magnifying glasses Body fluid Conductivity Precision High Low Reliability Immediacy of results Yes No Convenience of use Low cost of ownership Information content Can be used for birth control? Can be used to preselect baby’s sex? Can it do built-in pregnancy check? Can it compute date of delivery? Folliculogenesis profile for healthcare? Multi-purpose long-term use? The Ovulona provides the best quality, the most value per dollar spent “Price Is Not An Advertising Point In This Category” Of Trying-To-Conceive Women “Chief Selling Points Are Simplicity And Accuracy” [marketresearch.com] http://www.marketresearch.com/Packaged-Facts-v768/Home-Medical-Tests-143386/ See also “Corporate venturing: the origins of Unilever's pregnancy test“: http://dx.doi.org/10.1080/00076790412331270139. See MarketResearch.com: http://www.marketresearch.com/Packaged-Facts-v768/Home-Medical-Tests-143386/ In TOC scroll down to section IV. See also “Corporate venturing: the origins of Unilever's pregnancy test“ http://dx.doi.org/10.1080/00076790412331270139. 9

Sure Bet! Natural reproductive management is inevitably preferred over the alternatives IT IMPROVES QUALITY OF PLEASURE We humans are pleasure - seeking organisms OUR FUNDAMENTAL DRIVING FORCE Our brain prefers “ancient” sensory pleasures - including “natural” sex Ref.: ANTHROPOLOGY –“The Pursuit of Pleasure” by Lionel Tiger, 1992