MARIO NEGRI INSTITUTE: First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086 ENVIRONMENTAL HEALTH SCIENCES MARIO NEGRI INSTITUTE: 1961 - 2016 Goodmorning to everyone, in this short presentation i’m going to introduce the Mario Negri Institute, its activitie and the main research topic of the group leaded by Ettore Zuccato. Riva Francesco Nutrition Toxicology Lab Milan, 29th February 2016

INSTITUTIONAL POLICY INDEPENDENT OF GOVERNMENT, POLITICS, UNIVERSITY AND INDUSTRY MULTIPLE SOURCES OF FINANCING, NO ONE AMOUNTING TO MORE THAN 10% OF THE ANNUAL BUDGET NONE OF OUR RESEARCH RESULTS ARE PATENTED PRIVATE ENTERPRISE SERVING PUBLIC INTERESTS First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

LOCATIONS Mario Negri Institute, Milano Center for Rare Diseases Aldo and Cele Daccò Ranica (Bg) Anna Maria Astori Bergamo (BG) Today the institute has three location, the main in Milan, a second one in Bergamo and a clinical research center for rare disease in Ranica. First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

international scientific journal 250 books more than 245.500 citations PERSONNEL 20 in 1961 550 in 2016 PUBLICATIONS 13000 scintific articles on international scientific journal 250 books more than 245.500 citations First Mario Negri Institute in Milano from the initial group of 20 people today the Institute has more than 500 employees and results of their activities are reported in over 13,000 publications and 250 books First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

DEPARTMENTS BIOMEDICAL ENGINEERING EPIDEMIOLOGY MOLECULAR BIOCHEM. AND PHARM. MOLECULAR MEDICINE NEUROSCIENCE The researchers' works is organized into 10 departments and the institute's main activities concern the medicine and pharmacology. Indeed the main research areas are the battle against cancer, cardiovascular and kidney diseases, rare diseases, epidemiology and public health.  Among theese departements the departement of Environmental health science works to investigate the presence of the contaminants in the environment and on the assessment of human exposure with related health risks. ONCOLOGY PUBLIC HEALTH RENAL MEDICINE CARDIOVASCULAR RESEARCH ENVIRON. HEALTH SCIENCES First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

ENVIRONMENTAL HEALTH SCIENCE DEPARTMENT OF ENVIRONMENTAL HEALTH SCIENCE Proteomics and Metabolomics. Molecular epidemiology used to identified genetic and/or environmental factor posing risk to human health. Risk assessment related to atmospheric pollution, contamination of soil, surface and ground waters. Evaluation of risk associated with contamination performed in vitro and in silico, Development and application of analithycal method for compounds of biological and environmental interest. First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

Thermo Q-exactive Orbitrap Thermo LTQ xl orbitrap Thermo Q-exactive Orbitrap Theese some of the instrument in our department... AbSciex triple quad. 5500 Agilent 6550 ifunnel Q-TOF First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

LAB OF NUTRITION TOXICOLOGY MAIN ACTIVITIES: Study the sources, presence, behavior, fate and effects of emerging environmental contaminants. Development and application of analytical methods for compounds of environmental interests. Estimate of the drug consumption in the population. Chemical contaminants in food and human nutrition. Into this departement The Laboratory of Ettore Zuccato studies the source and fate of emerging environmental contaminants such as pharmaceuticals, illicit drugs, personal care products developing analytical method for these pollutants. Other thopics are the study of human exposure to food contaminants including dioxines and PCBs. First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

ENVIRONMENTAL BIOMARKERS UNIT MAIN ACTIVITIES: Wastewater based epidemiology. Development of sewage biomarkers to be measured in urban wastewater. Evaluate human habits such as illicit drugs, alcohol and nicotine use. Assess human exposure to pesticides. Together with the environmental biomarker unit, leaded by Sara Castiglioni, our working group focused the attention on the Wastewater based epidemiology. The project started with cocaine and its metabolites, their levels in wastewater revealed that cocaine consumption greatly exceeds officials estimates. The approach has been extended to include other common drug of abuse and its able to detect consumption changes in real time complementing survey method and describe more realistically the drug consumption phenomenon. Now this approach include also nicotine, alcohol and other emerging contaminants like pesticides and mycotoxins. First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

WORKING GROUP Pharmaceuticals Environmental Risk Assessment Illicit Drugs Micotoxines WW based epidemiology Illicit Drugs Nitrosammines WW based epidemiology Pesticides WW based epidemiology First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

MAIN RESEARCH PROJECTS SEWPROF (Marie Curie ITN # 317205): A new paradigm in drug use and human health risk assessment: Sewage profiling at the community level. Cost Action ES1307: Sewage biomarkers analysis for community health assessment. Aqua Drugs (National Agency for Drug Policy): “Estimates of drug use in the population by analysis of wastewater.” Cariplo Rif. 2013-1550 (Fondazione Cariplo): “Assessment of the environmental distribution of a number of new emerging and unconventional pollutants, to guide actions to protect the environment and in particular the surface and underground water.” Theese and other research activities were conducted within several projects, including a cost action on sewage biomarker analysis, a collaboration with the national Agency for Drug policy for the estimates of drug use in the population and a project whit the SEWPROF network. First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086

Thank you for your attention First plenary meeting of the project HOME/2014/JDRU/AG/DRUG/7086