Measles Rubella Meeting

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Presentation transcript:

Measles Rubella Meeting 22nd June, 2016 Dr. Craig Burgess, JSI

Overview Multi Dose Containers (MDCs): framing the issue & trade offs considered Phase 1: April – Oct 2015 Phase 2: Dose Per Container Partnership (DPCP) Nov 2015 – December 2017 Broader context

Framing the issue DPC changes impact system performance MDC can decrease price & cold chain storage But: new vaccines > expensive: may increase reluctance to open vial for every child More evidence needed for global & country decisions on DPC trade-offs between costs & system impacts (coverage)

Phase 1: April – Oct 2015 Summarizing evidence gaps: Evaluation of existing data and highlighting gaps in data and processes for decision making Methods: Literature review, informal surveys, key informant interviews, and stakeholder meeting Partnership: Creation of informal network of interested partners Funder, implementer, output

MDC trade-offs considered for assessment Evidence to better understand & inform decision making: Price per dose purchased Cost & impact on health system (coverage) Supply / cold chain / volume per dose Decision on when to open / risk of contamination Wastage rate Shifting burden to HCW Communication

Illustrating trade offs Total system effectiveness analysis provides a framework for evaluating trade-offs of a vaccine or intervention.

Changes in Doses per Container: Phase 2: DPCP Nov 2015 – Dec 2017 Gather data and document current practices / policies / systems for deciding how many doses per container Changes in system: Coverage (equity, timeliness, session size) Wastage rates Cost benefit Safety Cold Chain, Supply Chain and distribution capacity Healthcare worker behaviour & needs Document effect of these changes Changes in Doses per Container: Tanzania & Senegal MR & Birth dose HepB # dose per vial Evidence used to: Inform global processes & supply for doses per container (multiple antigens) Country level guidance & tools: produce a simple and easy to use tool that outlines the tradeoffs that are considered when making product selection decisions, demonstrates best practices and guides decision makers for product forecasting, planning, selection and ordering

Phase 2: DPCP Partnership

Work Stream 1 Document & assess national policies and processes for decision-making, including product selection, quantification, ordering, and financing 2 country case studies to understand historical decisions Key stakeholder interviews Looking at existing tools to inform decision making Documentation of when and how DPC is part of regular processes

Work Stream 2 Prospective implementation research SENEGAL TANZANIA Antigen Hep B @ birth (co-coverage BCG) Measles-Rubella @ 9 & 18 months Vial dose change 10 (liquid - Crucell) to 1 (liquid - LG Life Sciences) 10 (lyophilized - SII) to 5 (lyophilized - SII) Districts / Sample Size 2 regions: 8 districts (4 control; 4 intervention) 125 HFs (62 in control arm; 63 in intervention arm) 3 regions: 7 districts 246 HFs (123 in control & 123 HFs in intervention arm) Vaccinated target population 40,627 130,000 Lead PATH and MOH JSI and MOH

Work Stream 2 Prospective implementation research Systems aspects Vaccine purchase costs, cost per dose and total systems costs, equitable & timely coverage, open vial vaccine wastage, immunization session & frequency, logistics storage & distribution capacity & costs, missed opportunities, drop out rate, safety & HCW behavior. Methodology & tools 12 month retrospective data collection. Field based implementation research with one intervention and one control arm. Pre- and post- cross sectional design to measure difference in qualitative and quantitative indicators between arms. Key informant interviews, observing HCW behavior, registers, data collection tools, cold chain assessment, registers & quantitative data collection tools.

Work Stream 2 August 2016: baseline data collection September 2016 – August 2017: implementation / introduction & monitoring new presentation September 2017: end line data collection

Work Stream 3 Coordination: partners, links to others (eg. CDC, industry) Modeling: with HERMES & others Communication: website, results, TechNet, GIN, via partners & TAG Cost benefit Technical Advisory Group (TAG): broad range of 8 individuals, objective strategic guidance (incl. WHO / UNICEF SD / GAVI / industry & countries)

End Results Global stakeholders: evidence filling critical knowledge gaps in analysis and policy making processes, guiding stakeholders to make informed, sustainable decisions on DPC when considering vaccine products and program designs Country stakeholders: Produce easy-to- use and -understand guides & tools to assess DPC tradeoffs, including cost and systems impact to inform vaccine product selection.

Broader context Ethiopia study Wastage studies: Cambodia 2013 & Nigeria 2012 (issues on MCV MDVP), Ghana and possibly Fiji HERMES Benin / Mozambique MR / BCG / penta vial size: wastage & supply chain Industry impact

References / contacts TechNet Dose per Container Partnership Group www.technet-21.org/en/network/groups/item/196-dose Sarah Melendez (sarah_melendez@jsi.com) Craig Burgess (craig_burgess@jsi.com) JSI website www.jsi.com/immunization