Volume 151, Issue 6, Pages (June 2017)

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Volume 151, Issue 6, Pages 1229-1238 (June 2017) Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock Paul E. Marik, MD, FCCP, Vikramjit Khangoora, MD, Racquel Rivera, PharmD, Michael H. Hooper, MD, John Catravas, PhD, FCCP CHEST Volume 151, Issue 6, Pages 1229-1238 (June 2017) DOI: 10.1016/j.chest.2016.11.036 Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 1 Predicted and actual mortality in the treatment and control groups. Predicted mortality was derived from APACHE IV scoring system results. *P < .001 for comparison of treatment group vs control group (see text). APACHE = Acute Physiology and Chronic Health Evaluation. CHEST 2017 151, 1229-1238DOI: (10.1016/j.chest.2016.11.036) Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 2 Time course of vasopressor dose (in norepinephrine equivalents) in the treatment group and in the control group survivors and nonsurvivors. *P < .001 for comparison of treatment group vs control group (see text). CHEST 2017 151, 1229-1238DOI: (10.1016/j.chest.2016.11.036) Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 3 Time course of the SOFA score over the 4-day treatment period in the treatment group and in the control group survivors and nonsurvivors. ∗P < .001 for comparison of treatment group vs control group (see text). SOFA = Sepsis-Related Organ Failure Assessment. CHEST 2017 151, 1229-1238DOI: (10.1016/j.chest.2016.11.036) Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 4 Time course of the PCT score over the 4-day treatment period in the treatment group and in the control group plotted on a semilog scale. ∗P < .001 for comparison of treatment group vs control group (see text). PCT = procalcitonin. CHEST 2017 151, 1229-1238DOI: (10.1016/j.chest.2016.11.036) Copyright © 2016 American College of Chest Physicians Terms and Conditions