Innate Immunity: The Immediate Response to Infection Peter Parham The Immune System Fourth Edition Chapter 2 Innate Immunity: The Immediate Response to Infection Copyright © Garland Science 2015

CHAPTER CONTENTS 2-1 Physical barriers colonized by commensal microorganisms protect against infection by pathogens 2-2 Intracellular and extracellular pathogens require different types of immune response 2-3 Complement is a system of plasma proteins that mark pathogens for destruction 2-4 At the start of an infection, complement activation proceeds by the alternative pathway 2-5 Regulatory proteins determine the extent and site of C3b deposition 2-6 Phagocytosis by macrophages provides a first line of cellular defense against invading microorganismstes

CHAPTER CONTENTS 2-7 The terminal complement proteins lyse pathogens by forming membrane pores 2-8 Small peptides released during complement activation induce local inflammation 2-9 Several classes of plasma protein limit the spread of infection 2-10 Antimicrobial peptides kill pathogens by perturbing their membranes 2-11 Pentraxins are plasma proteins of innate immunity that bind microorganisms and target them to phagocytes

Innate Immunity: the Immediate Response to Infection 2-1 Physical barriers colonized by commensal microorganisms protect against infection by pathogens

2-1 Physical barriers colonized by commensal microorganisms protect against infection by pathogens

Innate Immunity: the Immediate Response to Infection 2-2 Intracellular and extracellular pathogens require different types of immune response

2-2 Intracellular and extracellular pathogens require different types of immune response

Innate Immunity: the Immediate Response to Infection 2-3 Complement is a system of plasma proteins that mark pathogens for destruction

2-3 Complement is a system of plasma proteins that mark pathogens for destruction

2-3 Complement is a system of plasma proteins that mark pathogens for destruction

2-3 Complement is a system of plasma proteins that mark pathogens for destruction

Innate Immunity: the Immediate Response to Infection 2-4 At the start of an infection, complement activation proceeds by the alternative pathway

2-4 At the start of an infection, complement activation proceeds by the alternative pathway

2-4 At the start of an infection, complement activation proceeds by the alternative pathway

2-4 At the start of an infection, complement activation proceeds by the alternative pathway

Innate Immunity: the Immediate Response to Infection 2-5 Regulatory proteins determine the extent and site of C3b deposition

2-5 Regulatory proteins determine the extent and site of C3b deposition

Innate Immunity: the Immediate Response to Infection 2-6 Phagocytosis by macrophages provides a first line of cellular defense against invading microorganisms

2-6 Phagocytosis by macrophages provides a first line of cellular defense against invading microorganisms

Innate Immunity: the Immediate Response to Infection 2-7 The terminal complement proteins lyse pathogens by forming membrane pores

2-7 The terminal complement proteins lyse pathogens by forming membrane pores

2-7 The terminal complement proteins lyse pathogens by forming membrane pores

2-7 The terminal complement proteins lyse pathogens by forming membrane pores

2-7 The terminal complement proteins lyse pathogens by forming membrane pores

2-7 The terminal complement proteins lyse pathogens by forming membrane pores

2-7 The terminal complement proteins lyse pathogens by forming membrane pores

Innate Immunity: the Immediate Response to Infection 2-8 Small peptides released during complement activation induce local inflammation

2-8 Small peptides released during complement activation induce local inflammation

Innate Immunity: the Immediate Response to Infection 2-9 Several classes of plasma protein limit the spread of infection

2-9 Several classes of plasma protein limit the spread of infection

Innate Immunity: the Immediate Response to Infection 2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

2-10 Antimicrobial peptides kill pathogens by perturbing their membranes

Innate Immunity: the Immediate Response to Infection 2-11 Pentraxins are plasma proteins of innate immunity that bind microorganisms and target them to phagocytes

2-11 Pentraxins are plasma proteins of innate immunity that bind microorganisms and target them to phagocytes