Prevention of stricture development after corrosive esophageal burn with a modified esophageal stent in dogs Jing-Hai Zhou, MD, Yao-Guang Jiang, MD,

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Presentation transcript:

Prevention of stricture development after corrosive esophageal burn with a modified esophageal stent in dogs Jing-Hai Zhou, MD, Yao-Guang Jiang, MD, Ru-Wen Wang, MD, Shi-Zhi Fan, MD, Tai-Qian Gong, PhD, Qun-You Tan, PhD, Zheng Ma, PhD, Yun-Ping Zhao, PhD, Bo Deng, MD The Journal of Thoracic and Cardiovascular Surgery Volume 136, Issue 5, Pages 1336-1342.e7 (November 2008) DOI: 10.1016/j.jtcvs.2008.02.086 Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Schematic diagram of a modified esophageal stent. A long piece of nitinol string transfixed the upper metal circumference of the modified esophageal stent. Silicone membrane exceeding the upper metal cage by 1 cm was affixed to the inside and outside of the stent. Plastic valves were attached to the lower end of the modified esophageal stent. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1336-1342.e7DOI: (10.1016/j.jtcvs.2008.02.086) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

A modified esophageal stent that was removed from an animal in group D. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1336-1342.e7DOI: (10.1016/j.jtcvs.2008.02.086) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Light microscopic studies on the esophageal tissue in dogs Light microscopic studies on the esophageal tissue in dogs. (Hematoxylin and eosin stain, original magnification 200×.) A, Fibroblast cells with a large amount of irregularly arranged collagen deposition in group B. B, Less fibroblast cells and collagen bundles with regular orientation in group D compared with those in group B. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1336-1342.e7DOI: (10.1016/j.jtcvs.2008.02.086) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Transmission electron microscopic studies of the esophageal tissue in dogs. (Original magnification 4200×.) A, Irregularly arranged collagen bundles in group B. B, Thinner collagen bundles with regular orientation in group D compared with those in group B. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1336-1342.e7DOI: (10.1016/j.jtcvs.2008.02.086) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Reverse transcriptase–polymerase chain reaction showing of an electrophoretogram of TGF-β1, Smad3, and Smad7 mRNA in esophageal tissue in dogs. TGF-β1 and Smad3 levels decreased and Smad7 levels increased in the stented group compared with those in the untreated group. β-actin was used as the control gene. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1336-1342.e7DOI: (10.1016/j.jtcvs.2008.02.086) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Western blot showing chemiluminescent film of TGF-β1, Smad3, and Smad7 protein in esophageal tissue in dogs. TGF-β1 and Smad3 levels decreased and Smad7 levels increased in the stented group compared with those in the untreated group. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1336-1342.e7DOI: (10.1016/j.jtcvs.2008.02.086) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions