Is it PCOS… or are your Adrenal Glands Overreacting?

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Presentation transcript:

Is it PCOS… or are your Adrenal Glands Overreacting? By: Carrie Jones, ND, MPH

Disclosures: Medical Director of Precision Analytical, Inc Copyright 2017: Carrie Jones, ND, MPH

Copyright 2017: Carrie Jones, ND, MPH

Diagnosis: 2 out of 3 1) Androgen excess (labs and symptoms) 2) Ovulatory dysfunction 3) Polycystic Ovarian Morphology Copyright 2017: Carrie Jones, ND, MPH

Is obesity part of the diagnosis? Not always 30%-75% are obese Copyright 2017: Carrie Jones, ND, MPH

Insulin resistance  hyperinsulinemia Obesity ↓ SHBG Theca cells enlarge ↑ Testosterone Antral dev. stops/Anovulation ↓ Progesterone Copyright 2017: Carrie Jones, ND, MPH

Androgens The Adrenals produce roughly: The Ovaries produce roughly: 25% of the Testosterone 50% of the Androstenedione 80% of the DHEA 100% of the DHEA-s The Ovaries produce roughly: 25% of the Testosterone 50% of the Androstenedione  20% of the DHEA (not DHEA-s) The other 50% of Testosterone is made in adipose tissue via androstenedione conversion Copyright 2017: Carrie Jones, ND, MPH

What you’re telling me is… maybe it’s the Adrenal Glands? Copyright 2017: Carrie Jones, ND, MPH

Copyright 2017: Carrie Jones, ND, MPH

CASE STUDY 33yo female Recent(!) history of irregular cycles Acne and hirsutism High stress, Gut inflammation Normal BMI Copyright 2017: Carrie Jones, ND, MPH

Estradiol = upper end of the range DHEA-s = high Testosterone = high Progesterone = low Estrone = high Estradiol = upper end of the range DHEA-s = high Testosterone = high Copyright 2017: Carrie Jones, ND, MPH

She’s making a ton of cortisol = everything in the red! Copyright 2017: Carrie Jones, ND, MPH

What do you do? Where do you start? Is it really PCOS? Copyright 2017: Carrie Jones, ND, MPH

First, address the cause In the case study, high stress and gut inflammation is likely upregulating the HPA axis resulting in high cortisol (weight gain, irregular cycles), and elevated androgens (acne and hirsutism) Copyright 2017: Carrie Jones, ND, MPH

And then… Focus on diet and lifestyle Address blood sugar and insulin if it’s an issue Improve cortisol levels! Restore ovulation, improve estrogen balance Reduce androgenic symptoms Copyright 2017: Carrie Jones, ND, MPH

Thank you for listening! Copyright 2017: Carrie Jones, ND, MPH