FIG. 1. Scanning electronic microscope image of the unmodified beads; all the bead samples were identical in appearance and size to the unmodified shown.

Slides:

Advertisements

Similar presentations

Fig. 1. Effects of DIM, 5,5′-dibromoDIM and DIM-c-pPhtBu on Panc-1 and Panc-28 cell proliferation. Cells were treated with Me 2 SO (solvent.

Advertisements

From: An open day in the metric space

Figure 5. The relationship between hepatic lymphocyte subsets, hepatosteatosis and perisinusoidal fibrosis. Hepatosteatosis was associated with ( a )

Fig. 6 Gene expression and DNA methylation in callus

(A) The binding between purified prothrombin and V5-His-RPN2 (filled circle) was confirmed by ELISA. BSA (filled triangle) was used as the control. The.

Fig. 1 Graphical representation

Figure 7. Interaction between C9orf72 dipeptides and ribonucleotides in vivo. The concentration of RNA extracted from immunoprecipitated samples from NSC34.

Figure 1. CD11b+CD33+CD14+HLA-DR−/lo myeloid-derived suppressor cell expansion by human immunodeficiency virus.

Figure 2. CONSORT flow diagram.

Figure 1 Cumulative chance of pregnancy according to age at initiation of pregnancy seeking. The curves were drawn based on the following assumptions:

Fig. 1 GBM TIMs expand to inhibit vaccine-induced T-cell mediated tumor cytolysis via PD-1/PD-L1 regulatory pathway. (A, D) CD163, DAPI, (B, E) PD-L1,

Figure 1. Validation of BCP rat models (A) Radiological images of the MRMT-1-injected and Hank’s buffer-injected left hindpaw of the rats, 21 days after.

Figure 1. Intact autophagosome–lysosome fusion, but impaired autolysosome clearance in NPC1-deficient cells. (A) Representative images of human dermal.

FIG. 1. Characterization data of nano-TiO2 samples, including TEM images of nano-TiO2 particles in its (A) anatase, (B) anatase/rutile.

Fig. 1. Serum activity of the osteoclast-specific enzyme TRAP-5b and serum levels of RANKL and OPG, key regulators involved in osteoclast differentiation.

Fig. 1. Map of sample collection sites.

From: Soil temperature modifies effects of soil biota on plant growth

Fig. 3. Mean percentage of landing (a) and mean trapped R

Figure 3. Examples of tweets classified as ridicule.

Figure 1. Blue light inactivation of Acinetobacter baumannii and keratinocytes in vitro. Bars denote SDs. From: Antimicrobial Blue Light Therapy for Multidrug-Resistant.

Figure 1. Standardized coefficients for the SEM group model for heterosexual males. Latent constructs are shown in ellipses, and observed variables are.

Representative flow cytometry dot plots from a healthy individual

Figure 1. Conceptual model of well-being related to involvement in theatre. From: Theatre Involvement and Well-Being, Age Differences, and Lessons From.

Fig. 1 Flow of ascertainment of cases with incident childhood IgA vasculitis reported by four sources From: Incidence of IgA vasculitis in children estimated.

Fig. 1. Geographic locations of Shenzhen and Dongguan

Figure 1. Herbacetin binds to AKT1/2 and suppresses each respective kinase activity. The effect of herbacetin on (A) PI3K/AKT and (B) MAPK signaling pathway.

Figure 1 (A) Chest computed tomography scans of the patient

Fig. 1. Immunostaining for AhR in non-neoplastic urothelium ( A ), superficial UC ( B ) and invasive UC ( C ). ( A ) Weak cytoplasmic staining in the.

From: Grammatical rhymes in Polish poetry: A quantitative analysis

Fig. 1. (A) Final distribution of S

From: Where do we go from here

Example 14. Schubert, Quartet in G Major, D

Fig. 2 Expression and subcellular localization of MSL8–GFP expressed from endogenous sequences. (A) Quantitative RT–PCR amplification of MSL8 transcripts.

Fig. 1 Selection of patients

Figure 1. Academic productivity and high academic income: top earners vs. the rest of academics. The average number of ‘peer-reviewed article equivalents’

Fig. 1 Sample COMPRENO tree (automatically generated, no manual corrections) From: Text mining War and Peace: Automatic extraction of character traits.

From: Estimating the Location of World Wheat Price Discovery

Figure 1. Time of initiation of therapeutic hypothermia according to who initiated it. Note the logarithmic scaling of the vertical axis. From: Initiation.

FIG. 1. Various models of rate variation across sites and lineages

Fig 1 Distribution of GlideScope® videolaryngoscopy and direct laryngoscopy patients from the Paediatric Difficult Intubation Registry. GVL,

Figure 3. Biodistribution of Nickel was measured by using ICP-OES technique in (a) liver, (b) kidneys, (c) brain, (d) spleen, (e) heart, (f) blood, (g)

Figure 1. Progression-free survival and overall survival for FL/DLBCL patients. From: Clinicobiological features and prognostic impact of diffuse large.

Figure 1. Percentage of participants in each group (holocaust survivors, prewar immigrants, and postwar immigrants) by the main coded strategies. From:

FIG. 4. Working lifetime combined risk from fatal heart disease and lung cancer based on Hong Kong exposure to secondhand tobacco smoke and both US and.

Activated neutrophils and platelet microaggregates impede blood filterability through microchannels during simulated extracorporeal circulation Yukihiro.

Figure 1. Herbacetin binds to AKT1/2 and suppresses each respective kinase activity. The effect of herbacetin on (A) PI3K/AKT and (B) MAPK signaling pathway.

Human Immunodeficiency Virus Type 1 Protease Inhibitor Modulates Activation of Peripheral Blood CD4+ T Cells and Decreases Their Susceptibility to Apoptosis.

Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin αIIbβ3 by Cindy L. Yap, Karen.

Complement-Independent, Peroxide-Induced Antibody Lysis of Platelets in HIV-1- Related Immune Thrombocytopenia Michael Nardi, Stephen Tomlinson, M.Alba.

by Herbert Bosshart, and Ruth F. Jarrett

Rohun U. Palekar, BS, Chandu Vemuri, MD, Jon N

Quinine-induced thrombocytopenia: drug-dependent GPIb/IX antibodies inhibit megakaryocyte and proplatelet production in vitro by José Perdomo, Feng Yan,

Neutrophil aggregation is selectively induced by PS+ platelets

Interleukin 18 binding protein (IL18-BP) inhibits neointimal hyperplasia after balloon injury in an atherosclerotic rabbit model Jian-Ming Li, MD, Mohammad.

Volume 102, Issue 10, Pages (May 2012)

Volume 3, Issue 1, Pages (January 2003)

Fig. 2 In vitro assessment of hESC-RPE cell sheets.

Volume 14, Issue 1, Pages (January 2004)

Fig. 7. NPs accumulate at sites of vascular obstruction.

Volume 119, Issue 1, Pages (July 2000)

(A–B) Images of US ... (A–B) Images of US assessment of both patients who developed peripheral arthritis during vedolizumab treatment undergoing US-guided.

Fig. 6. Rolling neutrophils extract membranes from fragile remnant PS+ platelets. Rolling neutrophils extract membranes from fragile remnant PS+ platelets.

(A, B) Representative TEM images from the skin ...

Fig. 3 CSF1 is expressed in human melanoma.

PD-L1 selectively marks circulating NCMs.

PD-L1 expression is maintained on NCMs under inflammatory conditions and PD-L1+NCMs are found in TLOs. PD-L1 expression is maintained on NCMs under inflammatory.

CD169+ macrophages mediate the transport of bacteria to T cell zones by trans-infecting CD8α+ DCs. CD169+ macrophages mediate the transport of bacteria.

Exo70 is recruited to the plasma membrane at sites of mechanical wounding. Exo70 is recruited to the plasma membrane at sites of mechanical wounding. NRK.

Volume 119, Issue 6, Pages (December 2000)

Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides In Vitro and in mdx Mice Mingxing Wang, Bo Wu, Sapana N. Shah, Peijuan.

Presentation transcript:

FIG. 1. Scanning electronic microscope image of the unmodified beads; all the bead samples were identical in appearance and size to the unmodified shown here. From: Surface Derivatization State of Polystyrene Latex Nanoparticles Determines both Their Potency and Their Mechanism of Causing Human Platelet Aggregation In Vitro Toxicol Sci. 2010;119(2):359-368. doi:10.1093/toxsci/kfq349 Toxicol Sci | © The Author 2010. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com

FIG. 2. Free-radical generation by polystyrene latex nanobeads with various surface modifications as measured by EPR with HBSS and 1mM pyrogallol as negative and positive controls, respectively. Tempone H (1mM) was used as the spin trap (***p< 0.001). Mean ± SEM values shown, n = 3. From: Surface Derivatization State of Polystyrene Latex Nanoparticles Determines both Their Potency and Their Mechanism of Causing Human Platelet Aggregation In Vitro Toxicol Sci. 2010;119(2):359-368. doi:10.1093/toxsci/kfq349 Toxicol Sci | © The Author 2010. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com

FIG. 3. Upper panel shows confocal microscopy images (original magnification ×100) showing platelet-platelet aggregates stained with CD42a-FITC (A) latex beads by UV illumination (B) and colocalization of beads and platelet aggregates using both forms of illumination (C). Lower panel (E) shows confocal microscopy images (original magnification ×100) showing a monocyte-platelet aggregate stained with CD14-PE (red color monocyte) and CD42a-FITC (green color platelets) overlain with the blue UV-illuminated NP (shown alone in D) to demonstrate a nanoparticle-platelet-monocyte complex. From: Surface Derivatization State of Polystyrene Latex Nanoparticles Determines both Their Potency and Their Mechanism of Causing Human Platelet Aggregation In Vitro Toxicol Sci. 2010;119(2):359-368. doi:10.1093/toxsci/kfq349 Toxicol Sci | © The Author 2010. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com

FIG. 4. Platelet aggregates formed in whole blood by treatment with aPLNP and cPLNP but not umPLNP. Bars represent mean + SEM of n = 3 separate experiments. From: Surface Derivatization State of Polystyrene Latex Nanoparticles Determines both Their Potency and Their Mechanism of Causing Human Platelet Aggregation In Vitro Toxicol Sci. 2010;119(2):359-368. doi:10.1093/toxsci/kfq349 Toxicol Sci | © The Author 2010. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com

FIG. 5. Platelet-monocyte aggregates following treatment of whole blood with the various PLNP. Asterisks denote significant difference from control—there was no difference between the levels of aggregates seen between the three PLNP. From: Surface Derivatization State of Polystyrene Latex Nanoparticles Determines both Their Potency and Their Mechanism of Causing Human Platelet Aggregation In Vitro Toxicol Sci. 2010;119(2):359-368. doi:10.1093/toxsci/kfq349 Toxicol Sci | © The Author 2010. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com

FIG. 6. Effect of Aqueous extract (AE) of beads on aggregate formation; note the vertical scale showing no significant platelet aggregation effects. Bars represent mean + SEM of n = 3 separate experiments. From: Surface Derivatization State of Polystyrene Latex Nanoparticles Determines both Their Potency and Their Mechanism of Causing Human Platelet Aggregation In Vitro Toxicol Sci. 2010;119(2):359-368. doi:10.1093/toxsci/kfq349 Toxicol Sci | © The Author 2010. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com

FIG. 7. Expression of CD62-P (P-selectin) and PAC-1 in platelets following treatment of whole blood with the various PLNP plus positive control TRAP; significant (p < 0.001) increase over NaCl seen only with cPLNP and TRAP. Bars represent mean + SEM of n = 3 separate experiments. From: Surface Derivatization State of Polystyrene Latex Nanoparticles Determines both Their Potency and Their Mechanism of Causing Human Platelet Aggregation In Vitro Toxicol Sci. 2010;119(2):359-368. doi:10.1093/toxsci/kfq349 Toxicol Sci | © The Author 2010. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com

FIG. 8. Expression of CD62-P (P-selectin) and PAC-1 following treatment with the various PLNP and the positive control TRAP (platelet agonist). cPLNP and TRAP caused significant binding of CD62-P and PAC-1 compared with saline control (***p < 0.001), umPLNP (†††*p < 0.001), and aPLNP (###p < 0.001). Mean ± SEM values shown, n = 3. From: Surface Derivatization State of Polystyrene Latex Nanoparticles Determines both Their Potency and Their Mechanism of Causing Human Platelet Aggregation In Vitro Toxicol Sci. 2010;119(2):359-368. doi:10.1093/toxsci/kfq349 Toxicol Sci | © The Author 2010. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com

FIG. 9. Percentage of cells with phosphatidylserine on the external face of the plasma membrane as measured by Annexin V binding in response to 260 μg/ml of umPLNP, aPLNP, and cPLNP. aPLNP and cPLNP showed a significant difference to control (*p < 0.0.01 and ***p < 0.001) and umPLNP († p< 0.01 and †††p < 0.001), and cPLNP differed significantly to the aPLNP (#p < 0.01). Mean ± SEM values shown, n = 4. From: Surface Derivatization State of Polystyrene Latex Nanoparticles Determines both Their Potency and Their Mechanism of Causing Human Platelet Aggregation In Vitro Toxicol Sci. 2010;119(2):359-368. doi:10.1093/toxsci/kfq349 Toxicol Sci | © The Author 2010. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com

FIG. 10. Red blood cell (RBC) hemolysis in response to increasing doses of umPLNP, aPLNP, cPLNP, and DQ12 quartz. umPLNP and cPLNP caused no RBC hemolysis. Quartz caused significant hemolysis at all doses (***p < 0.001). aPLNP resulted in highly significant hemolysis at 500 μg/ml (†††p < 0.001), and by 750 μg/ml, this was significantly different to quartz ($$$p < 0.001). Mean ± SEM values shown, n = 4. From: Surface Derivatization State of Polystyrene Latex Nanoparticles Determines both Their Potency and Their Mechanism of Causing Human Platelet Aggregation In Vitro Toxicol Sci. 2010;119(2):359-368. doi:10.1093/toxsci/kfq349 Toxicol Sci | © The Author 2010. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com

FIG. 11. Effect of 1, 5, and 10% plasma on hemolysis caused by aPLNP FIG. 11. Effect of 1, 5, and 10% plasma on hemolysis caused by aPLNP. There was no significant effect of 1% plasma, but 5 and 10% plasma cause significant inhibition of hemolysis **, p < 0.01 compared with 0% plasma. Mean ± SEM values shown, n = 3. From: Surface Derivatization State of Polystyrene Latex Nanoparticles Determines both Their Potency and Their Mechanism of Causing Human Platelet Aggregation In Vitro Toxicol Sci. 2010;119(2):359-368. doi:10.1093/toxsci/kfq349 Toxicol Sci | © The Author 2010. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com