The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet Min Hee Kim, Jongsung Lee, Sehyun.

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The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet Min Hee Kim, Jongsung Lee, Sehyun Jung, Joo Wan Kim, Jae-Ho Shin, Hae-Jeung Lee Journal of Ginseng Research Volume 41, Issue 2, Pages 120-126 (April 2017) DOI: 10.1016/j.jgr.2016.01.004 Copyright © 2017 Terms and Conditions

Fig. 1 Experimental study design. The rats were selected randomly and assigned to five groups. One group served as the control and was fed a normal diet (ND). The other four groups were fed a high-fat diet (HFD) containing 45% kcal from fat for 11 wk without ginseng berry (GB). Three of the HFD groups were additionally treated by gastric gavage with ginseng berry hot water extract (GBx) dissolved in distilled water at 50 (GBx 50) mg/kg, 100 (GBx 100) mg/kg, and 150 (GBx 150) mg/kg body weight for 6 wk. Journal of Ginseng Research 2017 41, 120-126DOI: (10.1016/j.jgr.2016.01.004) Copyright © 2017 Terms and Conditions

Fig. 2 High-performance liquid chromatography analysis of the ginsenoside Re in the ginseng berry extract powder. The major ginsenosides of the ginseng berry hot water extract were analyzed using high-performance liquid chromatography. Journal of Ginseng Research 2017 41, 120-126DOI: (10.1016/j.jgr.2016.01.004) Copyright © 2017 Terms and Conditions

Fig. 3 Liver histopathological images in the control group (A), high-fat diet (HFD) group (B), and groups treated with ginseng berry extract 50 mg/kg (C), 100 mg/kg (D), or 150 mg/kg (E) body weight together with a HFD. To examine hepatic histopathological changes in the control group, HFD, and groups treated with ginseng berry extract 50 mg/kg, 100 mg/kg, or 150 mg/kg body weight together with a HFD, Hematoxylin and Eosin and Oil red staining were performed as described in the Materials and methods section. CV, central vein; PT, potral triad. Journal of Ginseng Research 2017 41, 120-126DOI: (10.1016/j.jgr.2016.01.004) Copyright © 2017 Terms and Conditions

Fig. 4 Aortic histopathological images in the control group (A), high-fat diet (HFD) group (B), and groups treated with ginseng berry extract 50 mg/kg (C), 100 mg/kg (D), or 150 mg/kg (E) body weight together with a HFD. To examine aortic histopathological changes in the control group, HFD, and groups treated with ginseng berry extract 50 mg/kg, 100 mg/kg, or 150 mg/kg body weight together with a HFD, Hematoxylin and Eosin and Oil red staining were performed as described in the Materials and methods section. LU, Lumen. Journal of Ginseng Research 2017 41, 120-126DOI: (10.1016/j.jgr.2016.01.004) Copyright © 2017 Terms and Conditions