Autologous bone marrow mononuclear cell transplantation in ischemic heart failure: A prospective, controlled, randomized, double-blind study of cell transplantation.

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Presentation transcript:

Autologous bone marrow mononuclear cell transplantation in ischemic heart failure: A prospective, controlled, randomized, double-blind study of cell transplantation combined with coronary bypass Tommi Pätilä, MD, PhD, Miia Lehtinen, MD, Antti Vento, MD, PhD, Jukka Schildt, MD, Juha Sinisalo, MD, PhD, Mika Laine, MD, PhD, Pekka Hämmäinen, MD, PhD, Anne Nihtinen, MD, PhD, Riitta Alitalo, MD, PhD, Päivi Nikkinen, PhD, Aapo Ahonen, MD, PhD, Miia Holmström, MD, PhD, Kirsi Lauerma, MD, PhD, Reino Pöyhiä, MD, PhD, Markku Kupari, MD, PhD, Esko Kankuri, MD, PhD, Ari Harjula, MD, PhD The Journal of Heart and Lung Transplantation Volume 33, Issue 6, Pages 567-574 (June 2014) DOI: 10.1016/j.healun.2014.02.009 Copyright © 2014 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 1 Study flow diagram. The Journal of Heart and Lung Transplantation 2014 33, 567-574DOI: (10.1016/j.healun.2014.02.009) Copyright © 2014 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 2 Numbers of cells in various BMMC sub-populations and interquartile ranges. The Journal of Heart and Lung Transplantation 2014 33, 567-574DOI: (10.1016/j.healun.2014.02.009) Copyright © 2014 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 3 Change in LVEF measured by MRI. Circles: individual values; horizontal line: medians; whiskers: interquartile ranges. The Journal of Heart and Lung Transplantation 2014 33, 567-574DOI: (10.1016/j.healun.2014.02.009) Copyright © 2014 International Society for Heart and Lung Transplantation Terms and Conditions

Figure 4 (A) Medians and interquartile ranges of percentage of scar in each segment at baseline and at 1-year follow-up as measured by late-enhancement MRI. (B) Medians and interquartile ranges of change in scar volume in each segment. (C) Representative LGE-MRI images of LV short-axis slices pre-operatively and after 1-year follow-up in BMMC-injected patients and controls. The Journal of Heart and Lung Transplantation 2014 33, 567-574DOI: (10.1016/j.healun.2014.02.009) Copyright © 2014 International Society for Heart and Lung Transplantation Terms and Conditions