SWAG SSG Lung Cancer Meeting

Slides:



Advertisements
Similar presentations
UK Clinical Research Network (UKCRN) UK Clinical Research Network Maxine Stead PhD UKCRN Assistant Director – Clinical Trials.
Advertisements

Applying for additional funding for eligible* activity in CRN: Kent, Surrey and Sussex Applicant* Trust R&D for authorisation ( encouraged) Relevant.
Understanding Diabetes Dr Gill Hood North Thames Clinical Research Network Barts Health NHS Trust
Navigating the Networks Chantal Sunter July 2014.
Lung Cancer Research Report Site Specific Group Meeting Tuesday 11th November 2014 Maxine Taylor Senior Research Delivery Manager.
Janet Darbyshire (25 June 07) UK Clinical Research Network (UKCRN) Identifying research priorities in the UK Clinical Research Network.
Delivering clinical research to make patients, and the NHS, better Lymphs & Haems Cancer Research Report Site Specific Group Meeting Weds 11 th March 2015.
Delivering clinical research to make patients, and the NHS, better Breast Cancer Research Report Site Specific Group Meeting Tuesday 13 th January 2015.
Delivering clinical research to make patients, and the NHS, better Haematological Cancer Research Report Site Specific Group Meeting Tuesday 14 th October.
Upper GI Research and Clinical Trials Update Bridget Workman Research Manager NECRN N 21 ST November 2012.
Delivering clinical research to make patients, and the NHS, better Head & Neck Cancer Research Report Site Specific Group Meeting Tuesday 9 th June 2015.
Delivering clinical research to make patients, and the NHS, better Cancer Patients’ Experiences of Research Findings from the National Cancer Patient Experience.
Delivering clinical research to make patients, and the NHS, better Urology SSG 22nd April 2015 Research Wendy Cook, Research Delivery Manager Dr Mohini.
Delivering clinical research to make patients, and the NHS, better Cancer Patients’ Experiences of Research Findings from the National Cancer Patient Experience.
Delivering clinical research to make patients, and the NHS, better Lymphs & Haems Cancer Research Report Site Specific Group Meeting Wednesday 16 th March.
SWAG SSG Skin Meeting Thursday 22nd September 2016 Maxine Taylor
Engaging and Supporting Surgical Research: Clinical Research Networks
SWAG SSG Sarcoma Meeting
Genomic Medicine Centre Overview
Colorectal Cancer Research Report SWAG Site Specific Group
SWAG SSG Urology Meeting
SWAG SSG Haematology and Lymphoma Meeting
SWAG SSG Skin Cancer Meeting
Dr Shegufta Farooq Research Orthoptist Department of Orthoptics,
SWAG SSG Head and Neck Cancer Meeting
SWAG SSG Colorectal Cancer Meeting
Skin Cancer Research Report SWAG SSG Maxine Taylor Senior Research Delivery Manager 17/05/2016.
Breast Cancer Research Report SWAG Site Specific Group
SWAG SSG Upper GI Cancer Meeting
SWAG SSG Brain Meeting Wednesday 16th November 2016
SWAG SSG Sarcoma Meeting
SWAG SSG Breast Cancer Meeting
Haematology/Lymphoma Research Report SWAG Site Specific Group
SWAG SSG Upper GI Cancer Meeting
SWAG SSG Urology Cancer Meeting
SWAG SSG Upper GI Cancer Meeting
SWAG SSG Skin Cancer Meeting Tuesday 22nd May Research Report
West of England Genomic Medicine Centre: Our Progress to Date
SWAG SSG Haematology and Lymphoma Meeting
SWAG SSG Colorectal Meeting
SWAG SSG Haematology and Lymphoma Meeting
SWAG SSG Sarcoma Cancer Meeting
SWAG SSG Gynaecology Cancer Meeting
SWAG SSG Colorectal Cancer Meeting
SWAG SSG Brain and CNS Cancer Meeting
SWAG SSG Urology Meeting
SWAG SSG Lung Cancer Meeting
SWAG SSG Gynaecological Cancers Meeting
SWAG SSG Brain and CNS Cancer Meeting
SWAG SSG Skin Cancer Meeting
Mainstreaming Genomic Medicine post 100,000 Genomes Project
SWAG SSG Breast Cancer Meeting
SWAG SSG Head and Neck Cancer Meeting
SWAG SSG Sarcoma Meeting
SWAG SSG Head and neck Cancer Meeting
SWAG SSG Sarcoma Cancer Meeting
SWAG SSG Lung Cancer Meeting
Breast Cancer Research Report Site Specific Group Meeting Friday 10th July 2015 Dr Mark Beresford Network Sub Specialty Lead – Breast Cancer.
SWAG SSG Skin Cancer Meeting Wednesday 23rd May Research Report
SWAG SSG Haematology and Lymphoma Cancer Meeting
NIHR CRN High Level Objectives
SWAG SSG Lung Cancer Meeting
SWAG SSG Skin Cancer Meeting
Cancer specialty specific objectives
SWAG SSG Brain Cancer Meeting
SWAG SSG Breast Cancer Meeting
SWAG SSG Upper GI Cancer Meeting
Lung Cancer Clinical Advisory Group
Somerset, Wiltshire, Avon & Gloucestershire Cancer Alliance
Urology Cancer Clinical Advisory Group
Presentation transcript:

SWAG SSG Lung Cancer Meeting Clinical Research Network West of England SWAG SSG Lung Cancer Meeting Tuesday 15th November 2016 Research Report

Clinical Research Network & Cancer Services West ofEngland SWAG - Somerset Wiltsire Avon & Gloucestershire South West Children’s Cancer & Leukaemia Research Network

NIHR CRN – what does it do? Infrastructure that allows high-quality clinical research to take place in the NHS Help researchers to set up clinical studies quickly and effectively Support the life-sciences industry to deliver their research programmes in the NHS Provide health professionals with research training Work with patients to ensure their needs are at the very centre of all research activity.

NIHR CRN High Level Objectives Increase number of participants into NIHR CRN portfolio studies 650,000 in England 21,905 in West of England Increase the number of studies that deliver to time and target Target 80% Increase number of commercial studies delivered through network 650 new studies this year 75% of all commercial studies Reduce NHS study set up times Reduce time taken to recruit first participant

Local Clinical Research Networks Translation of national objectives for clinical research Oversight of research activity within the geography of CRN - West of England in terms of: Portfolio Balance, new studies, feasibility, set up, industry trials Performance Support, network wide solutions, targets People Patient involvement, staff skill mix & flexibility, training, resources

30 Clinical Specialties Ageing Anaesthetics & pain Cancer Cardiovascular Children Critical Care Dementia & Neurodegenerative Dermatology Diabetes ENT Gastroenterology Genetics Haematology Health Services Hepatology Infectious Diseases Injuries & Emergencies Mental Health Metabolic & Endocrine Musculoskeletal Neurological Opthalmology Oral & Dental Primary Care Public Health Renal Reproductive Health Respiratory Stroke Surgery

Including lymphoma

Local CRN sub specialty leads NCRI Clinical Studies Groups NIHR CRN cancer leadership

National Clinical Studies Groups PPI Psychosocial & Survivorship Imaging Adv. panel Breast Cancer CSG Brain Tumours CSG Lung Cancer CSG Palliative & Supportive Care Head & Neck CSG Biomarkers Adv. panel Upper GI Cancer CSG Consumer Liaison Group Sarcoma CSG PPI Colorectal Cancer CSG Melanoma CSG Kidney Cancer CSG Primary Care Lymphoma CSG Bladder Cancer CSG Screening, Prevention & Early Diagnosis Haematol. CSG Testis Cancer CSG Prostate Cancer CSG Gynae Cancer CSG Children’s Cancer & Leukaemia Teenage & Young Adult CTRad (Radiotherapy)

NIHR CRN Objectives for cancer Recruit 20% of cancer incidence West of England 1,909 Recruit 7.5% of cancer incidence into interventional studies 716 Include challenging studies Cancer surgery – 4 recruits per 100,000 population Radiotherapy – 6 recruits per 100,000 population Rare cancers (<6 per 100,000) – 12 recruits per 100,000 population Children & young people – 3 per 100,000 population Teenagers & young adults – record number of 16-25 year olds participating in research

Open studies in SWAG – Lung Cancer portfolio BRAG Open studies Black Study not reported recruitment or study has not recruited Red % Recruitment is more than 30 behind % time elapsed, i.e. Difference < -30 Amber % Recruitment is less than 30 behind % elapsed time but more than 0 behind % elapsed time, i.e. -30 < Difference < 0 Green % Recruitment is equal to or greater than % elapsed time, i.e. Difference >= 0 Grey Unable to calculate RAG due to record missing at least one data point

Open studies in SWAG – Lung Cancer portfolio

Studies in set up – Lung Cancer

Commercial studies with outstanding expressions of interest

JAVELIN open at Cheltenham. PI David Farrugia This trial give patients access to new immunotherapy (PD-1 Inhibitors) as first line treatment (currently only available to a sub population of patients with Pembrolizumab on EAMS provided they score at least 50% positivity on tumour testing). The EAMS programme will close as soon as the drug gets a licence.   This trial also allows crossover to the IMP on progression in the control arm.  This makes PD-L1 inhibitors as second line therapy available to our patients (rejected by NICE recently so no idea when this will be available on the NHS.) We are looking for motivated patients with PS0-1 who are willing to travel (expenses covered).

Useful links https://www.crn.nihr.ac.uk/ National and local network information including training programmes templates, tools, contacts, videos etc https://odp.nihr.ac.uk/ http:/ Open data platform. Look at performance across whole CRN including all specialty areas /csg.ncri.org.uk/portfolio/portfolio-maps/ View current national portfolio of open, closed and ‘in set up’ cancer studies https://www.ukctg.nihr.ac.uk/ See where a study is open across the country http://public-odp.nihr.ac.uk/  Search for a study to fit criteria. Good for horizon scanning, eligibility criteria

Contacts Research Delivery Manager – maxine.taylor@nihr.ac.uk Cancer portfolio facilitator – sarah.west@nihr.ac.uk