Volume 100, Issue 6, Pages 1028-1036 (June 2006) Development of chronic hypoventilation in amyotrophic lateral sclerosis patients  Daniele Lo Coco, Santino Marchese, Salvatore Corrao, Maria Cettina Pesco, Vincenzo La Bella, Federico Piccoli, Albino Lo Coco  Respiratory Medicine  Volume 100, Issue 6, Pages 1028-1036 (June 2006) DOI: 10.1016/j.rmed.2005.09.035 Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 1 Relationship between the absence of chronic hypoventilation (CH) and the time from study entry in the whole group of patients. Kaplan–Meier curve depicts the proportion of patients without CH according to the time since study entry (initial number of patients: 38). Respiratory Medicine 2006 100, 1028-1036DOI: (10.1016/j.rmed.2005.09.035) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 2 Relationship between the Appel ALS Rating Scale (AARS) category, the absence of chronic hypoventilation (CH) and the time from study entry. Kaplan–Meier curves depict the proportion of patients without CH according to the time since study entry. The patients (38) are grouped with respect to their AARS category (R=rapid progression, n:14; I=intermediate progression, n:10; S=slow progression, n:14). CH-free survival differed significantly among the three groups (P<0.0001 by the Log-Rank test). Respiratory Medicine 2006 100, 1028-1036DOI: (10.1016/j.rmed.2005.09.035) Copyright © 2005 Elsevier Ltd Terms and Conditions