Dose-dependent effects of omega-3-polyunsaturated fatty acids on systolic left ventricular function, endothelial function, and markers of inflammation.

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Presentation transcript:

Dose-dependent effects of omega-3-polyunsaturated fatty acids on systolic left ventricular function, endothelial function, and markers of inflammation in chronic heart failure of nonischemic origin Deddo Moertl, MD, Alexandra Hammer, MD, Sabine Steiner, MD, Raisa Hutuleac, MD, Karin Vonbank, MD, Rudolf Berger, MD American Heart Journal Volume 161, Issue 5, Pages 915.e1-915.e9 (May 2011) DOI: 10.1016/j.ahj.2011.02.011 Copyright © 2011 Mosby, Inc. Terms and Conditions

Figure 1 CONSORT diagram. American Heart Journal 2011 161, 915.e1-915.e9DOI: (10.1016/j.ahj.2011.02.011) Copyright © 2011 Mosby, Inc. Terms and Conditions

Figure 2 Effects of 3-month treatment with placebo, 1 g/d n3-PUFA, and 4 g/d n3-PUFA on: A, LVEF; B, FMD; and C, hsIL-6 levels. Data are presented as mean ± SD (A and B) and quartiles (C). American Heart Journal 2011 161, 915.e1-915.e9DOI: (10.1016/j.ahj.2011.02.011) Copyright © 2011 Mosby, Inc. Terms and Conditions

Figure 3 Dose-dependent increase of LVEF after treatment with 1 and 4 g/d n3-PUFA for 3 months. ⁎Post hoc test (linear trend for dose-dependent change), P = .01. American Heart Journal 2011 161, 915.e1-915.e9DOI: (10.1016/j.ahj.2011.02.011) Copyright © 2011 Mosby, Inc. Terms and Conditions