“Stronger Together We are” Daniel J. Sargent, PhD 1970-2016 I have the distinct honor and privilege to review Dan’s academic and professional career. I am deeply humbled to do this. “Stronger Together We are”

Wore Many hats… Section Head, Cancer Center Statistics, Mayo Clinic Chair, Division of Biomedical Statistics and Informatics Director, Biostatistics Shared Resource for the Mayo Clinic Cancer Center Group Statistician, Statistics and Data Center- Alliance for Clinical Trials in Oncology (2011-2016) North Central Cancer Treatment Group (2000 – 2010) PI on multiple federal, industry, and foundation awards

Academic Credentials Ralph S. and Beverley E. Caulkins Professor of Cancer Research at Mayo Clinic Professor of Biostatistics – Mayo Clinic College of Medicine Professor of Oncology – Mayo Clinic College of Medicine Adjunct Professor: Department of Biostatistics, University of Iowa Division of Biostatistics, University of Minnesota Department of Biostatistics & Bioinformatics, Duke University Medical Center

Education University of Minnesota – BS, Mathematics -1992 University of Minnesota – MS, Biostatistics -1994 University of Minnesota – PhD, Biostatistics -1996

Tenure at MAYO 1993: Intern Data Analyst – Division of Biostatistics, Mayo Clinic 1996: Research Associate – Cancer Center Statistics 1999: Associate Consultant – Cancer Center Statistics 2001: Senior Associate Consultant – Mayo Clinic 2005: Consultant – Division of Biostatistics, Mayo Clinic

Professional Leadership NIH/NCI Member, Clinical Trial Design Task Force, Investigational Drug Steering Committee(2008 – present) Co-Chair, CTWG Evaluation Subcommittee(2010 – 2012) Co-Chair, EORTC Working Group on Clinical Trial Methodology for Trials Involving Correlative Science(2002 – 2005) Chair, KRAS Mutant Committee, Colon Cancer Task Force (2008 – 2009) Chair, Scientific Review Group Subcommittee H-Clinical Trials (2003 – 2005) Chair/Member of 91 DMC’s

Professional Leadership Society for Clinical Trials President - 2013 – 2014 Fellow, SCT Member, Program Committee (2008 – 2010) Chair, Constitution and Bylaws Taskforce (2007 – 2012) American Society of Clinical Oncology Member, Clinical Meaningful Outcomes Workgroup (2012 – 2014) Member, Program Committee (2011)

Journal Editorial Responsibilities Associate Editor, Chinese Clinical Oncology Journal (2013 –) Editorial Board Member, European Journal of Cancer (2009 –) Editorial Board Member, Oncologist (2010 –)

Educational activities Teaching/Lectureship/Workshops 20 intramural 11 extramural Mentorship PhD Thesis – 4 individuals Innumerable summer interns!

Academic Interests Clinical Trial Conduct and Methodology Survival Analysis Clinical Trials Design Surrogate Endpoints Patient Reported Outcomes

Publications and Presentations Presentations: National/International/regional 136 309 Publications 33 First Author 96 Last Author 27 Book Chapters 4 First Author 23 Last Author 59 Letters, Editorials and Commentaries 13 First Author 32 Last Author 2 Book Reviews 2 First Author

Published in… Statistical Biometrics Statistics in Medicine Clinical Trials Clinical New England Journal of Medicine Journal of Clinical Oncology Journal of the National Cancer Institute JAMA

R01 CA174779 (2014 – 2018) Methodology for development, validation, and use of novel endpoints in oncology Aim 1: Enhance model-based phase I designs with novel multivariate endpoints. Aim 2: Develop new and improve existing methodology for patient-level and trial-level evaluation of surrogate endpoints in clinical trials. Aim 3: Develop novel adaptive phase II and III clinical trial designs specifically utilizing multiple endpoints (including surrogate endpoints) in the presence of biomarkers.

Remembering Dan “The first time I saw Dan, I thought I was seeing the first statistical child prodigy because he looked like he was about 12 years old. In fact, he was the usual age for a grad student, but he was wise far beyond his years.” “Dan was immensely proud of his roots. He never hesitated in describing the hard work of his parents in supporting him as a child, and their family landscaping business. I stopped trying to one-up him with my tree identification efforts!” “His children and wife were always part of his conversations with me. He once remarked that the one decision he regretted was waiting so long to start a family. He loved watching his children growing up – tennis, long-distance running and first dates.”

Remembering Dan “Dan had a permanent smile and interminable enthusiasm. He was a brilliant scientist, and he was so….alive!” “Dan’s remarkable legacy will carry on through decades of discoveries and advances in clinical translation... Moreover, he persists within each one of the numerous mentees inspired by him to pursue a life of research.” “I have known a number of Nobel Prize winners, but only one person I would characterize as a genius: that person is Dan Sargent.”

On a personal note Dan was a dear friend, and mentor, and helped shape my professional career. He was always there to support me through difficult times, personally and professionally. I will remember him forever for all the ideals and principles he has taught me. He always told me: opportunity never comes to the unprepared mind.

On a personal note He believed in the teams he built. He was always ready to take on new challenges, and thrived on new opportunities and challenges as those difficult situations always brought out the best in him. He was a strong leader with unwavering faith in himself and everyone that was part of his group. He was respectful and graceful in all his decisions as a leader, and a very bright scientist. I will remember him fondly forever