A randomized controlled trial comparing the efficacy and safety of two HMG preparations gaining their LH bioactivity from different HCG sources Gillian.

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Presentation transcript:

A randomized controlled trial comparing the efficacy and safety of two HMG preparations gaining their LH bioactivity from different HCG sources Gillian Lockwood, Barbara Cometti, Jeanette Bogstad, Karin Erb, Christian De Geyter, Janos Urbancsek, Silvia Trevisan, Khaled Pocate- Cheriet, Dominique de Ziegler Reproductive BioMedicine Online Volume 35, Issue 1, Pages 17-27 (July 2017) DOI: 10.1016/j.rbmo.2017.03.021 Copyright © 2017 IBSA Institut Biochimique SA Terms and Conditions

Figure 1 Trial flow chart and disposition of patients by trial visit. aPoor ovarian response (n = 3); risk of ovarian hyperstimulation syndrome (OHSS) (n = 3). bProtocol violation (n = 1); poor ovarian response (n = 1); OHSS risk (n = 2); continuation of the treatment not in the best interest of the patient (n = 1). cfailed fertilization (n = 7); risk of OHSS (n = 2); no progressing embryos (n = 1). dfailed fertilization (n = 4); risk of OHSS (n = 2); no progressing embryos (n = 2); poor embryos quality (n = 1). eOnly one ovary accessible for oocytes retrieval (n = 3). fInappropriate enrolment (poor responder patient) (n = 1). Reproductive BioMedicine Online 2017 35, 17-27DOI: (10.1016/j.rbmo.2017.03.021) Copyright © 2017 IBSA Institut Biochimique SA Terms and Conditions

Figure 2 Pregnancy and live birth data for the fresh and cumulative, i.e., fresh plus frozen, cycles per the intention-to-treat population (A) and the per-protocol population (B). P, not statistically significant for any of the parameters (Fisher's exact test for categorical variables); intention to treat population: n = 135 in both the Meriofert and in the Menopur group; per protocol patient population: n = 126 in the Meriofert group; n = 129 in the Menopur group. PP, per protocol population; ITT, intention-to-treat. Reproductive BioMedicine Online 2017 35, 17-27DOI: (10.1016/j.rbmo.2017.03.021) Copyright © 2017 IBSA Institut Biochimique SA Terms and Conditions

Figure 3 17-beta oestradiol levels. Daily serum concentrations (mean ± SE) of oestradiol during the administration of Meriofert and Menopur. t-test for treatment difference based on log-transformed values. Reproductive BioMedicine Online 2017 35, 17-27DOI: (10.1016/j.rbmo.2017.03.021) Copyright © 2017 IBSA Institut Biochimique SA Terms and Conditions