Xenotransplantation of Human Cord Blood Derived Unrestricted Somatic Stem Cells Rescue the Blistering Phenotype in a Murine Model of Recessive Dystrophic.

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Xenotransplantation of Human Cord Blood Derived Unrestricted Somatic Stem Cells Rescue the Blistering Phenotype in a Murine Model of Recessive Dystrophic Epidermolysis Bullosa Yanling Liao, PhD, Larisa Ivanova, PhD, Bhavishya Surapaneni, Ashlin Yahr, BA, Mitchell S. Cairo, MD Biology of Blood and Marrow Transplantation Volume 20, Issue 2, Pages S185-S186 (February 2014) DOI: 10.1016/j.bbmt.2013.12.304 Copyright © 2014 Terms and Conditions

Fig 1 A. Kaplan-Meier curve comparison between untreated and a single USSC intrahepatic injection, repeated intra-hepatic USSC injection, a single subcutaneous USSC injection and USSC conditioned medium injection. P<0.0001. B. Disappearance of hemorrhagic blisters in the paws of a representative RDEB mouse skin following USSC treatment. Biology of Blood and Marrow Transplantation 2014 20, S185-S186DOI: (10.1016/j.bbmt.2013.12.304) Copyright © 2014 Terms and Conditions

Fig 2 A. Time course BLI on a representative RDEB mouse that received USSC injection. B. Imaging of dissected internal organs on days 0 and 2.1, liver. 2, lung, 3, stomach and digestive system, 4, pancreas, 5, spleen, 6, heart and 7, kidney. Biology of Blood and Marrow Transplantation 2014 20, S185-S186DOI: (10.1016/j.bbmt.2013.12.304) Copyright © 2014 Terms and Conditions