Copyright © 2013 American Medical Association. All rights reserved. From: Primary Cutaneous CD4+ Small- to Medium-Sized Pleomorphic T-cell LymphomaTemporary Remission by Oral Doxycycline JAMA Dermatol. 2013;149(8):956-959. doi:10.1001/jamadermatol.2013.4162 Figure Legend: Histopathologic Findings, Hematoxylin-Eosin A and B, A dense, nodular infiltrate composed of small- to medium-sized pleomorphic lymphocytes in the entire dermis. A, Lymphocytes show folliculotropism and focally epidermotropism (original magnification ×10.) B, Lymphocytes showed cytologic atypia with irregular nuclear membranes and hyperchromatic nuclei (original magnification ×40). C, Most of the lymphocytes express CD4 (original magnification ×10). D, Most of the lymphocytes coexpress CD5 (original magnification ×10). E, Many CD4+ lymphocytes coexpress CD10 (original magnification ×10). F, Staining for CD20 shows many CD20+ B lymphocytes, representing almost half of the infiltrate (original magnification ×10). Date of download: 9/30/2017 Copyright © 2013 American Medical Association. All rights reserved.

Copyright © 2013 American Medical Association. All rights reserved. From: Primary Cutaneous CD4+ Small- to Medium-Sized Pleomorphic T-cell LymphomaTemporary Remission by Oral Doxycycline JAMA Dermatol. 2013;149(8):956-959. doi:10.1001/jamadermatol.2013.4162 Figure Legend: The Patient’s Right CheekA, A solitary, sharply demarcated erythematous tumor. B, Six weeks after therapy with oral doxycycline monohydrate (200 mg/d for 21 days), the tumor on the right cheek showed a complete remission. C, Thirteen months after the end of the doxycycline therapy the patient presented with erythematous, unsharply demarcated, and scaly plaques of the right cheek. Date of download: 9/30/2017 Copyright © 2013 American Medical Association. All rights reserved.