Genomic study of multiple myeloma based on aCGH and NGS

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Genomic study of multiple myeloma based on aCGH and NGS Blood cancer of mature plasma cells Normoploid profile (del(13), del(17)(p), t(4;14)) >>>BAD prognosis Hyperdiploid profile (trisomy of odd chromosomes) >>>GOOD prognosis Unreliable classification !! I will present briefly the results of my project intitled ,,,. Mmis a ,,, patients can be divide in 2 based on genomic prfile,,, but unrealiable because many ,,, In this study we try to detect ,,,,on a cohort of 95 patients and this data link with,,, Genomic abnormalities High resolution SNP-aCGH Punctual mutations High throughput exome sequencing Clinical data Subclassification of multiple myeloma

Genomic study of multiple myeloma based on aCGH and NGS Xa Xa Xi 45% of the patients show X chromosome alteration AR XIAP BCORL1 IRAK IKBKG … results obtain by cgh are represented by this heatmap which show in ble box patient,,, and in orange box patients ,,, but we also detected many alte with unknown prognosis impact it s the case for,,, If we look at NGS data we can see here for these 2 patients with partial deletion that the kept region is characterized by a loh, it mean that we are not in this condition but rather in ,,, Based on these observations we ask the question QUID about the genes in the conserved region sometimes implicated in apoptosis or in cell prolif? To answer this question we performed a screening of theirexpression. The results are available on my poster and i invite you to come and have a discussion about that. Xi deletion Loss of heterozygosity on Xq region