Volume 129, Issue 3, Pages (March 2006)

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Volume 129, Issue 3, Pages 509-517 (March 2006) Effects of Tiotropium With and Without Formoterol on Airflow Obstruction and Resting Hyperinflation in Patients With COPD van Noord Jan A. , MD, PhD, FCCP, Aumann Joseph L. , MD, Janssens Eduard , MD, Verhaert Jan , MD, Smeets Joseph J. , PhD, Mueller Achim , PhD, Cornelissen Piet J.G. , PhD CHEST Volume 129, Issue 3, Pages 509-517 (March 2006) DOI: 10.1378/chest.129.3.509 Copyright © 2006 The American College of Chest Physicians Terms and Conditions

Figure 1 Study design. *There was no wash-out period between each crossover treatment phase. TIO = tiotropium; PLA = placebo; FORM = formoterol; Labs = laboratory tests. CHEST 2006 129, 509-517DOI: (10.1378/chest.129.3.509) Copyright © 2006 The American College of Chest Physicians Terms and Conditions

Figure 2 Mean FEV1 before (24-h baseline) and at the end of 2-week treatment periods, adjusted for period, center, and patient within center. *p < 0.05 tiotropium qd plus formoterol bid vs tiotropium qd. #p < 0.05 tiotropium qd plus formoterol qd vs tiotropium qd. †p < 0.05 tiotropium qd plus formoterol bid vs tiotropium qd plus formoterol qd. CHEST 2006 129, 509-517DOI: (10.1378/chest.129.3.509) Copyright © 2006 The American College of Chest Physicians Terms and Conditions

Figure 3 Mean FVC before (24-h baseline) and at the end of 2-week treatment periods, adjusted for period, center, and patient within center. *p < 0.05 tiotropium qd plus formoterol bid vs tiotropium qd. #p < 0.05 tiotropium qd plus formoterol qd vs tiotropium qd. †p < 0.05 tiotropium qd plus formoterol bid vs tiotropium qd plus formoterol qd. CHEST 2006 129, 509-517DOI: (10.1378/chest.129.3.509) Copyright © 2006 The American College of Chest Physicians Terms and Conditions

Figure 4 Mean IC before (24-h baseline) and at the end of 2-week treatment periods, adjusted for period, center, and patient within center. *p < 0.05 tiotropium qd plus formoterol bid vs tiotropium qd. #p < 0.05 tiotropium qd plus formoterol qd vs tiotropium qd. †p < 0.05 tiotropium qd plus formoterol bid vs tiotropium qd plus formoterol qd. CHEST 2006 129, 509-517DOI: (10.1378/chest.129.3.509) Copyright © 2006 The American College of Chest Physicians Terms and Conditions

Figure 5 Mean 2-weekly number of puffs of rescue salbutamol per day. NS = not significant. CHEST 2006 129, 509-517DOI: (10.1378/chest.129.3.509) Copyright © 2006 The American College of Chest Physicians Terms and Conditions