Martin Stotz, MD, Hans-Peter Oehen, MD, Helmut Gerber, MD 

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Histological Findings After Long-Term Infusion of Intrathecal Ketamine for Chronic Pain  Martin Stotz, MD, Hans-Peter Oehen, MD, Helmut Gerber, MD  Journal of Pain and Symptom Management  Volume 18, Issue 3, Pages 223-228 (September 1999) DOI: 10.1016/S0885-3924(99)00069-X

Fig. 1 Management trials and related pain scores on pain scale during hospitalization in a 72-year-old patient with pain due to peritoneal malignant mesothelioma Journal of Pain and Symptom Management 1999 18, 223-228DOI: (10.1016/S0885-3924(99)00069-X)

Fig. 2 Detailed infusion scheme for intrathecal treatment with ketamine Journal of Pain and Symptom Management 1999 18, 223-228DOI: (10.1016/S0885-3924(99)00069-X)

Fig. 3 Severe lymphocytic vasculitis of spinal vessel after long-term intrathecal infusion of ketamine with preservative, normal medullary tissue; stained hematoxylin–eosin Journal of Pain and Symptom Management 1999 18, 223-228DOI: (10.1016/S0885-3924(99)00069-X)

Fig. 4 Normal nerve sheaths with central axon, no signs of demyelinization or vacuolization in the same patient; stained Klüver-Barrera Journal of Pain and Symptom Management 1999 18, 223-228DOI: (10.1016/S0885-3924(99)00069-X)