Laboratoire d’imagerie fonctionnelle et métabolique

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Presentation transcript:

Laboratoire d’imagerie fonctionnelle et métabolique LIFMET Laboratoire d’imagerie fonctionnelle et métabolique Prof. Rolf Gruetter (rolf.gruetter@epfl.ch) Orateur: Guillaume Donati (guillaume.donati@epfl.ch) www.cibm.ch

What is Biochemical imaging? Get informations from the interior of a living system Reveal internal structure and/or metabolism without surgery X-rays: Röntgen (1895) CT : Hounsfield and Cormack (1970) Echography : Wild and Reid (1951) MRI : Lauterbur and Mansfield (1971) PET (1950s)

Which disciplines are used? Maxwell equations simulations Mathematics Photons-matter interactions Engineering Neuroscience Physics Build devices What is measured Spin resonance Biochemistry Medicine Medical or research applications

Physics in LIFMET Physics of nuclear and electron spin (MRI-MRS): (Quantum mechanics) Small animal 9.4T scanner Human 7T scanner Small animal 14T scanner

Physics in LIFMET Positron emission tomography (imaging anti-matter annihilation, Compton scattering) O HO OH γ 511 keV OH 18O- 18F Fluorodeoxyglucose Glucose 511 keV

Current projects

Motion correction using fat navigator

MRI of human heart Difficult because the heart is always beating…

13C MRS in human brain Design and build a device to detect the 13C nuclei in the human brain

Glioblastoma (GBM) mouse xenografts derived from freshly injected human cells Normal/healthy Next challenges: Analyze the longitudinal evolution of GBM and eventual differences between patients Glioma/brain tumor Contact: Marta Lai: marta.lai@epfl.ch Cristina Cudalbu: cristina.cudalbu@epfl.ch

Projets TP IV et master: voir www.cibm.ch (site anglais) Impact of advanced image distortion correction on task and resting-state fMRI statistics Characterization of resting state networks & artefacts obtained with 2D and 3D fMRI sequences at high field High Sensitivity coil design for mouse/rat imaging at 9.4 /14 T Optimized Representation of 3D RF Sensitivity Fields for human brain imaging MR image quality at 7T in the presence of an EEG system Etc… rolf.gruetter@epfl.ch guillaume.donati@epfl.ch

Merci pour votre attention rolf.gruetter@epfl.ch guillaume.donati@epfl.ch www.cibm.ch