Volume 120, Issue 4, Pages (March 2001)

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Presentation transcript:

Volume 120, Issue 4, Pages 806-815 (March 2001) Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short- bowel patients with no colon Palle Bekker Jeppesen, Bolette Hartmann, Jesper Thulesen, Jesper Graff, Jette Lohmann, Birthe Stenbæk Hansen, Flemming Tofteng, Steen Seier Poulsen, Jan Lysgaard Madsen, Jens Juul Holst, Per Brøbech Mortensen Gastroenterology Volume 120, Issue 4, Pages 806-815 (March 2001) DOI: 10.1053/gast.2001.22555 Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 1 Relative absorption of energy and macronutrients before and after 5 weeks of GLP-2 treatment in 8 patients with the short-bowel syndrome. Closed symbols represent patients receiving HPN. *Paired Student t test. Δ, Mean ± SD effect of treatment with GLP-2 compared with baseline. Gastroenterology 2001 120, 806-815DOI: (10.1053/gast.2001.22555) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 2 Relative absorption of wet weight, sodium, potassium, and calcium before and after 5 weeks of GLP-2 treatment in 8 patients with the short-bowel syndrome. Closed symbols represent patients receiving HPN. *Paired Student t test. Δ, Mean ± SD effect of treatment with GLP-2 compared with baseline. Gastroenterology 2001 120, 806-815DOI: (10.1053/gast.2001.22555) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 3 Time to 50% gastric emptying of the solid marker (20 MBq of 99mTc-stannous colloid) and liquid marker (4 MBq of 111In-diethylenetriamine pentaacetic acid) before and after 5 weeks of GLP-2 treatment in 7 patients with the short-bowel syndrome. Closed symbols represent patients receiving HPN. *Paired Student t test. Δ, Mean ± SD effect of treatment with GLP-2 compared with baseline. Gastroenterology 2001 120, 806-815DOI: (10.1053/gast.2001.22555) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 4 Measurements of the villus heights and crypt depths before and after 5 weeks of treatment with GLP-2 in 8 patients with the short-bowel syndrome. Closed symbols represent patients receiving HPN. *Paired Student t test. Δ, Mean ± SD effect of treatment with GLP-2 compared with baseline. Gastroenterology 2001 120, 806-815DOI: (10.1053/gast.2001.22555) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 5 Plasma GLP-2 levels at fasting and 30 minutes after subcutaneous injection of 400 μg GLP-2. Gastroenterology 2001 120, 806-815DOI: (10.1053/gast.2001.22555) Copyright © 2001 American Gastroenterological Association Terms and Conditions