Automated Echo | Rapid Heart Imaging

What is the Whoosh? Automated heart and lung imaging for the youngest patients Ultrasound (echocardiography) that does not require a skilled user Paradigm changing technology for newborns and pediatric patients Self-guided, machine learning-based diagnostic tool to improve access and timely medical care

Why is the Whoosh needed? Newborns and infants lack access to echocardiography Less than 1/3 of U.S. hospitals have trained pediatric echo techs and appropriate equipment onsite Less than 5% of medical facilities in developing countries have access to devices appropriate for newborn and pediatric heart imaging

Why is the Whoosh needed?

Why is the Whoosh needed? Tele-Echo Study 59% of neonates had a change in medical management or required cardiology follow‐up due to diagnostic echo findings Close the Gap Automated diagnostic echo imaging for will Improve outcomes Reduce delayed and inaccurate diagnosis Assist in timely transfer decisions Reduce costs for patients, providers and payers Reduce trauma for family and baby

Number of Surveyed Hospitals % of Surveyed Hospital Births Same Day Neonatal Echo is Not Available 55/88 (62.5%) 25.6% Prostaglandin E1 Not Available in Hospital 51/88 (58%) 26% Transfer out of State for Higher Level of Neonatal Care 19/88 (21.6%) 13.6% What problems can the Whoosh solve? Close geographic gaps More than 50% of newborns > one hour from nearest pediatric heart center, appropriate imaging/echo Expedite diagnostic imaging to reduce mortality, morbidity, and disability associated with delayed, missed diagnosis or misdiagnosis Democratize access Rural/remote health staffers, emergency/transport, health workers in low-resource settings Miles Average Distance from Hospitals Without Neonatal Echo to Hospitals with Higher Level of Care 53.15

What problems can the Whoosh solve? Cost Average cost of current pediatric ultrasound technology: $100,000 + Portable machines still tens of thousands of dollars, limited quality, capability for newborns, infants Size 4’x5’x2’ | Weight: 200+ lbs Technical Current equipment limited to highly trained clinicians and techs

How are we accelerating the idea? Timing Microboards and image processing NOT previously available (same tech used in new self-driving cars) Catalyst Leverage role of universal newborn screening for CHD as (US and abroad) Capacity Prototype eliminates need for hand-held probe, manual positioning or specialty training to acquire clinically appropriate ultrasound/echo images How are we accelerating the idea?

How are we accelerating the idea? Prototype utilizes standardized echo transducers, reformatted into a blanket array Blend existing imaging components and capabilities with machine-learning, software-based, embedded predictive algorithms Stand alone data acquisition tool - embedded storage, electronic transmission capability How are we accelerating the idea?

How did we further the idea? Level 1 CDS Interface Supports Range of Users Green, Yellow, Red denote level of heart compromise Newborn Nursery Post Discharge Neonatal Nurses ER Physicians Pediatrician, GP Pediatrician, GP Nurse Practitioner Paramedics Midwife Critical Transport Teams Triage Nurses Neonatologists, ICU Level 2 Interface Transmits data to provider OR to off-site specialist | pediatric cardiologist

What are we building? Hyper-simplified data acquisition for range of users and settings Comfortable, simple to use, non-invasive for youngest patients Transducers | sensors reusable, scalable Iterative machine-learning interface processes, stores and transmits ultrasound imaging and echo data Interpretation occurs with specialist (remotely)

Who wants the Whoosh? 2,200,000 365,000 Babies born each day Newborn and Infant mortality single largest unmet Millennium Development Goal….what if a simple, low-cost tool could reduce infant mortality by 25%? 1,200 2,200,000 365,000 10,500 Babies born each day Babies Die each day Newborn lives that can be saved each day Potential Lives saved by year 5

Hospita Administrators Newborn HeartConnect: Next Steps Hospita Administrators It is not a matter of choosing which disease a child should die from, but rather of finding innovative technologies and sustainable solutions to provide high-quality treatment for all children