An Overview of the Research Institute 2017 Professor Nicholas Forsyth Director, Institute for Science & Technology in Medicine, Keele University

www.keele.ac.uk Keele University A campus-based university located in the West Midlands of England, offering dual-honours degrees and research in science, social science and humanities. Founded as a University College in 1949, it received its Royal Charter in 1962.

Guy Hilton Research Centre Huxley Building and extension 2017 David Weatherall Bldg McKay Building Guy Hilton Research Centre

“translating basic science insights into medical application through provision of a multidisciplinary research environment” ISTM brings together clinicians and bio-scientists across three hospital sites and the Keele campus: University Hospital of North Midlands, Hartshill, Stoke-on-Trent The Haywood Hospital, Burslem, Stoke-on-Trent Robert Jones & Agnes Hunt Orthopaedic Hospital, Oswestry School of Medicine School of Pharmacy School of Health & Rehabilitation School of Life Sciences ISTM Away Day 2016

Translational Research “bench to bedside” Industrial Partnership Industrial Partnership Potential Clinical application Clinical Trial Basic science Cell biology/ Physics/ Biological Chemistry Bioengineering/ Imaging/ In vitro/ In vivo modelling

ISTM - Current Staff 56 full members: - Professors: 17 - Readers: 3 - Senior Lecturers: 11 - Lecturers: 20 - Research Fellows: 5 Many affiliated members from other Keele RI’s Key chair appointments of senior clinical/non clinical academics to expand capacity Early Career Researchers recruited in Schools of Medicine, Pharmacy and SHAR

ISTM – Executive Committee Director: Prof Nicholas Forsyth Director of Postgraduate Studies: Prof Paul Horrocks Theme leads: Prof Alicia El Haj Dr Alan Richardson Dr Ed Chadwick

ISTM – Scientific themes Regenerative Medicine Healthcare Technologies Therapeutics http://www.keele.ac.uk/istm/researchareas/

Regenerative Medicine Theme leader: Prof Alicia El Haj Basic research into cell physiology and pathology, to developing new therapies in the laboratory, translating to treatments in the clinic and then assessing their efficacy by running clinical trials. European Centre of Excellence in Tissue Engineering. ARUK Centre of Excellence (+ Newcastle, Aberdeen, York) EPSRC Doctoral Training Centre in Regenerative Medicine (+ Loughborough and Nottingham) Part of 2 UK Regenerative Medicine Platform (UKRMP) hubs

Healthcare Technologies Theme leader: Dr Ed Chadwick Uses science and engineering principles to tackle the physical limitations brought on by neuromuscular and skeletal disease, injury and ageing: Investigating biomechanical and physiological causes Developing Assistive devices to restore function Mathematical and conceptual models for biomedical and rehabilitation engineering research.

Therapeutics Theme leader: Dr Alan Richardson Basic and translational research into human disease that will ultimately lead to new therapies. Neuroscience Cancer Nanotherapeutics Medicines use plus: fertility, genetic epidemiology, drug delivery, platelets, malaria

Quality definitions

ISTM Income from HEFCE QR and Research Grants & Contracts 2011/12 to 2015/16 QR figures supplied by David Myatt: £1,709,352 forecast for 2015/16

ISTM – Postgraduate Training PhD / Mphil / DM level research training, part- or full-time. Masters courses: Biomedical Engineering Cell & Tissue Engineering Engineering Design Growing cohort of overseas students, eg Iraq students. Annual Symposium PGR training activities new PGR students at the Guy Hilton Research Centre 2016

ISTM – Training Researchers Mentoring early-career lecturers and fellows Research fellows transition to independence Grant crafting and support panel ~35 research assistants and technical staff Support and activities: eg Keele ACORN studentships, start-up funds incl. HEFCE Capital Equipment funds, workshops.

International links to ISTM International links include China, Malaysia, India, Saudi Arabia, USA International research facilities, eg French synchrotron Researcher exchanges – eg ERASMUS Funded international projects – eg MagNETicFUN, European Research Council Fellow (Prof Mel Mather)

ISTM - Enterprise Activities Industrial collaborations, eg: - Innovation UK collaborative projects MRC, BBSRC CASE and EPSRC CDT studentships, with UK companies European joint projects involving Small & Medium Sized Enterprises Collaborative and contract research with UK / worldwide companies, eg: Athersys Inc (Cleveland, USA), Charnwood Molecular Ltd (Nottingham BioCity UK), Patara Pharma LLC (San Diego, USA), InterMune UK Ltd (Welwyn GC, UK), Glaxo SmithKline (London, UK), Lucideon Ltd (Stoke-on-Trent, UK), PneumaCare Ltd (Cambridge UK), Wolters Kluwer Health Ltd (Netherlands), XenoGesis Ltd (Nottingham BioCity UK). Licensing of Intellectual Property MRDC bid Examples of current spin-off companies from ISTM: NanoTherics (www.nanotherics.com) Mica Biosystems (http://micabiosystems.com/)

Web pages and contacts: www.keele.ac.uk/istm/ PA to Director: Tracy Stanyer +44 (0)1782 674087 t.stanyer@keele.ac.uk Director: Prof Nicholas Forsyth +44 (0)1782 674388 n.r.forsyth@keele.ac.uk Business Operations Manager: Jeanette Forrester +44 (0)1782 674381 j.forrester@keele.ac.uk RI Manager: Mark Smith +44 (0)1782 674967 m.e.smith@keele.ac.uk