Borrelia burgdorferi Gram-negative helical shaped spirochete bacteria

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Presentation transcript:

Borrelia burgdorferi Gram-negative helical shaped spirochete bacteria L. Haupt F2013 Modified by DYH Borrelia burgdorferi Gram-negative helical shaped spirochete bacteria 1 μm wide; 10-25 μm long Flagella located inside the periplasm between the inner and outer cell membranes Able to travel through viscous fluids and materials (i.e. tissues) Uses NAG as an E source Causative agent of Lyme disease – tick transmission Stage 1 infection causes rashes, fatigue, fever, headache, and muscle and joint aches Stage 2 infection causes facial palsy, meningitis, extreme joint pain, and heart palpitations Stage 3 infection causes arthritis and severe joint pain and swelling microbewiki.kenyon.edu borreliaburgdorferi.org

Borrelia burgdorferi Large linear chromosome with 910,725 bps 21 other linear and circular plasmids May encode virulent DNA Ip25 genes involved in infection BBE22 encodes a nicotinamidase Tick produces Salp15 – binds to B. burgdorferi and protects it from host immune system Mechanisms of infection are not well known Outer surface proteins OspA and OspC promote survival OspA more prevalent while in tick; OspC more prevalent while in human Uses small mammals as hosts, infection of humans is inadvertent Nature Reviews Microbiology