UNYTE Translational Research Network R. C. Block MD1, T UNYTE Translational Research Network R.C. Block MD1, T. Fogg MS, MPH1, F. S. Kaufman, BA2, G.D. Morse, PharmD2, T. Pearson MD, MPH, PhD1 1University or Rochester Medical Center – Clinical and Translational Science Institute; 2University at Buffalo – NYS Center of Excellence in Bioinformatics and Life Sciences Rochester Institute of Technology Bio-X builds on RIT's core technical strengths to address biological, health-care, and medical challenges National Technical Institute for the Deaf Lab for Environmental Computing and Decision Making Policy and economic impacts of health issues NY Chiropractic College Biomechanics Laboratory Neuromuscular Research Laboratory Roswell Park Cancer Institute NCI-designated comprehensive cancer center Center for Pharmacology and Therapeutics University at Buffalo Center for Computational Research Center of Excellence in Bioinformatics and Life Sciences Institute for Healthcare Informatics Center for Unified Biometrics and Sensors Center for Advanced Photonics & Electronic Materials Guthrie Health System Guthrie Practice Based Research Network Guthrie Research Institute Cardiovascular Disease 20-25 clinical trials Oncology 35 - 40 clinical trials Syracuse University Syracuse Biomaterials Institute (SBI) Aging Studies Institute Center of Excellence in Environmental and Energy Systems Cornell University Human Metabolic Research Unit Cornell Institute for Nutritional Genomics Binghamton University Center for Advanced Information Technologies Center for Applied Community Research and Development Center for Development and Behavioral Neuroscience Clinical Science and Engineering Research Center Trudeau Institute Research Emphasis: Influenza, Tuberculosis, Tropical Diseases, Sepsis & Coagulation, The Aging Immune System, Cancer Immunology SUNY Albany Gen*NY*Sis Center for Excellence in Cancer Genomics Center for Neuroscience Research The RNA Institute SUNY Upstate Medical University Upstate Cancer Research Institute Diabetes, Metabolic Disorders & Cardiovascular Disease; Disorders of the Nervous System; SUNY Eye Institute; Infectious Diseases & Emerging Pathogens Clinical Research Unit Masonic Medical Research Laboratory Cardiovascular Research focused on genetics, mechanisms and treatments of cardiac arrhythmias. Molecular Genetics; Molecular Biology; Cardiac electrophysiology and Induced Pluripotent Stem Cells Bassett Healthcare Network, Research Institute Divisions: Basic Science, Rural Community Health, Clinical Research, and Biostatistics & Computing Bassett School-Based Health Program Occupational injury and illness; Behavior change Community-based health interventions Rensselaer Polytechnic Institute Center for Biotechnology and Interdisciplinary studies Computational Center for Nanotechnology Innovations Upstate New York Shared Human Stem Cell Research Center Scientific Computation Research Center Albany Medical College Four Interdisciplinary Research Centers; Cardiovascular Sciences, Cell Biology and Cancer Research, Immunology and Microbial Diseases; Neuropharmacology and Neuroscience Industry-funded clinical research studies across multiple specialties conducted by Anesthesiology, Medicine, Neurology/Neurosciences, Pediatrics and Surgery Albany College of Pharmacy Pharmaceutical Research Institute Research Institute for Health Outcomes Special emphasis in infectious disease, sepsis, nephrology, GI, and health outcomes research. Wadsworth Center, NYS DOH NYS Reference Laboratory/ Public Health Research Center Infectious Disease and Host Defense; Molecular Genetics and Genomics; Neuroscience; Molecular and Cellular Basis of Disease; Environmental Health Science Special expertise in 3D electron microscopy, x-ray crystallography, brain computer interface, bioinformatics, biomonitoring University of Rochester Clinical and Translational Science Institute is one of the original 12 CTSAs Clinical research through the Center for Human Experimental Therapeutics; Clinical Research Center; Center for Research Implementation and Translation and Center for Community Health Clinical and Translational Science Building will serve as an institutional and regional hub for clinical and translational research OVERVIEW The University of Rochester Clinical and Translational Science Institute initiated the UNYTE Translational Research Network as a key function of its Clinical and Translational Sciences Award (CTSA). UNYTE is a consortium of biomedical research centers and academic research centers performing clinical and translational research within the Upstate New York and surrounding regions. The network utilizes a shared administrative leadership structure with the SUNY University at Buffalo New York State Center of Excellence in Bioinformatics and Life Sciences. It was the first CTSA Program to develop such a regional network. The goal of this key function is to further develop this model consortium as a “Regional Home for Translational Research” and foster scientific and economic growth. UNYTE CTSA Pilot Award Program Awardees (2010-2013) Recent Accomplishments UNYTE has developed a novel web-based central inventory of the research resources available at each member institution in addition to core areas of expertise. The Research Resource Database enables investigators to facilitate collaboration among member institutions and identify necessary resources needed to successfully conduct proposed multi-institutional research. UNYTE has also developed a custom NIH RePORTER Database of NIH funded grants and contracts awarded to UNYTE institutions. The Research Project Database is an on-line, searchable inventory of research projects that have taken place at UNYTE institutions. The information may help users find collaborators or mentors across UNYTE via the database’s fast and easy search tools. YEAR PROJECT TITLE PI and INSTITUTION CO-INVESTIGATOR and INSTITUTION 2010 The Upstate New York Network for Collaborative Biomedical Imaging Axel W.E. Wismueller, MD, PhD (PI) Avice M. O'Connell, MD, (University of Rochester) Andrzej Krol, PhD, Wei Lee, PhD (Upstate Medical University) Protein Kinase C Activation and Inhibition of VLDL Triglyceride Export Defines a Mechanism for Development of Non-Alcoholic Fatty Liver Disease Janet Sparks, PhD (University of Rochester); Michael Greene (Bassett Research Institute) 2011 Regional Stat Tumor Procurement to Support Studies of Lymphoma Richard Burack, MD, PhD (University of Rochester) Robert Hutchison, MD (SUNY Upstate); Tipu Nazeer, MD (Albany Medical College Consultant) 2012 Validity of Self-Reported Data for Studying Cognitive Problems and Depression Katia Noyes, PhD, MPH (University of Rochester) Ralph Benedict, PhD (University of Buffalo); Bianca Weinstock-Guttman, MD  (University at Buffalo) Andrew Goodman, MD (University of Rochester); Barbara Teter,  PhD (New York State Multiple Sclerosis Consortium Consultant); 2013 Regional Ultrasound Wall Strain Measurements to Predict Risk of Abdominal Aortic Aneurysm (AAA) rupture Ankur Chandra, MD, RPVI (University of Rochester) Karl Schwarz, MD (University of Rochester); Steven Day, PhD (Rochester Institute of Technology); Dan Phillips, PhD (Rochester Institute of Technology) Determining the interplay of Lymphoma Cells with its Microenvironment using a Novel In vivo Model Steven H. Bernstein, MD, (University of Rochester) Richard Burack, MD, PhD(University of Rochester); Shannon Hilchey, PhD (University of Rochester); Richard Bankert, VMD, PhD (University at Buffalo) Research Resource Database Research Project Database Administrative Structure Federally Funded Multi-Institutional Grant Activities Current Priorities and Future Direction Continue to foster clinical and translational research collaboration among UNYTE institutions Identify member institution needs that will promote training and expertise in clinical and translational research Foster innovation among UNYTE institutions that will lead to novel clinical and translational research programs that are competitive for federal funding. Maximize collaboration within the UNYTE geographic region that includes community-based patient organizations, industry partnerships and urban and rural health care settings. Utilize information technology and communications systems to promote regionalization of scientific research that addresses the needs of patients in our communities. TITLE PI and COLLABORATORS Rochester Bridges to the Doctorate (NIH R25) Thomas Pearson, MD, MPH, PhD (co-PI UR) Peter Hauser, Ph.D. (co-PI RIT) Researcher Resilience through Multidimensional Mentoring-Pathfinder (NIH Director’s Office ARRA) Vivian Lewis, MD (UR) Collaborators: UB, SUNY Upstate Genetic Risk of Neurocognitive Disorders in Patients with HIV Infection (NIH K08) Qing Ma, PhD (UB) Collaborators: UR, Vanderbilt Fish Oil Effects on Cardiovascular Disease Risk in Diabetics (NIH R21) Robert Block, MD, MPH (UR) Collaborators: ACP, Cornell Research technology U grant: CyTOF Mass Cytometer for Western NY Tim Bushnell (UR) Collaborators: UB, Roswell Park, Cornell UR CTSI Center for Experimental Therapeutics (NIH NCATS) Karl Kieburtz, MD, MPH (UR) Collaborators: UB, ACP Acknowledgments: UNYTE recognizes the vision of Dr. Bruce A. Holm to establish strategic partnerships with the University of Rochester and UNYTE members to collaborate in building the capacity for translational research across upstate New York. UR CTSA award # UL1 RR 024160; UB subaward 5UL1RR024160-04.