Copyright © 2001 American Medical Association. All rights reserved. From: Physiological Changes During Carbon Dioxide Inhalation in Patients With Panic Disorder, Major Depression, and Premenstrual Dysphoric DisorderEvidence for a Central Fear Mechanism Arch Gen Psychiatry. 2001;58(2):125-131. doi:10.1001/archpsyc.58.2.125 Figure Legend: Minute ventilation data were analyzed comparing 2 groups (subjects with panic disorder [PD] [n = 44] vs other diagnoses [n = 60]) and panic status (subjects who panicked [n = 29] and subjects who did not [n = 75]) during the first 5 minutes of 5% carbon dioxide (CO2) inhalation. Sex is the covariate. Statistics include the following: sex, F1,99 = 15.06, P<.001; group, F1,99 = 3.13, P= .08; panic, F1,99 = 18.08, P<.001; group × panic, F1,99 = 3.99, P= .048; time, F3,300 = 141.32, P<.001; group × time, F3,300 = 2.28, P= .08; panic × time, F3,300 = 8.48, P<.001; and group × panic × time, F3,300 = 0.68, P= .57. Date of download: 10/2/2017 Copyright © 2001 American Medical Association. All rights reserved.

Copyright © 2001 American Medical Association. All rights reserved. From: Physiological Changes During Carbon Dioxide Inhalation in Patients With Panic Disorder, Major Depression, and Premenstrual Dysphoric DisorderEvidence for a Central Fear Mechanism Arch Gen Psychiatry. 2001;58(2):125-131. doi:10.1001/archpsyc.58.2.125 Figure Legend: Respiratory rate data were analyzed comparing 2 groups (subjects with panic disorder [PD] [n = 44] vs other diagnoses [n = 60]) and panic status (subjects who panicked [n = 29] and subjects who did not [n = 75]) during the first 5 minutes of 5% carbon dioxide (CO2) inhalation. Sex is the covariate. Statistics include the following: sex, F1,99 = 19.00, P<.001; group, F1,99 = 0.34, P= .56; panic, F1,99 = 5.52, P= .02; group × panic, F1,99 = 0.03, P= .85; time, F2.5,249 = 5.55, P= .002; group × time, F2.5,249 = 1.96, P= .13; panic × time, F2.5,249 = 2.00, P= .13; and group × panic × time, F2.5,249 = 0.91, P= .42. Date of download: 10/2/2017 Copyright © 2001 American Medical Association. All rights reserved.

Copyright © 2001 American Medical Association. All rights reserved. From: Physiological Changes During Carbon Dioxide Inhalation in Patients With Panic Disorder, Major Depression, and Premenstrual Dysphoric DisorderEvidence for a Central Fear Mechanism Arch Gen Psychiatry. 2001;58(2):125-131. doi:10.1001/archpsyc.58.2.125 Figure Legend: Tidal volume data were analyzed comparing 3 groups (subjects with panic disorder [PD] [n = 44] vs other diagnoses [n = 60]) and panic status (subjects who panicked [n = 29] and subjects who did not [n = 75]) during the first 5 minutes of 5% carbon dioxide (CO2) inhalation. Sex is the covariate. Statistics include the following: sex, F1,99 = 28.44, P<.001; group, F1,99 = 2.98, P= .09; panic, F1,99 = 4.09, P= .046; group × panic, F1,99 = 6.69, P= .01; time, F3.2,315 = 74.60, P<.001; group × time, F3.2,315 = 191, P= .12; panic × time, F3.2,315 = 1.41, P= .24; and group × panic × time, F3.2,315 = 1.07, P= .36. Date of download: 10/2/2017 Copyright © 2001 American Medical Association. All rights reserved.

Copyright © 2001 American Medical Association. All rights reserved. From: Physiological Changes During Carbon Dioxide Inhalation in Patients With Panic Disorder, Major Depression, and Premenstrual Dysphoric DisorderEvidence for a Central Fear Mechanism Arch Gen Psychiatry. 2001;58(2):125-131. doi:10.1001/archpsyc.58.2.125 Figure Legend: End-tidal carbon dioxide (ETCO2) data were analyzed comparing 2 groups (subjects with panic disorder [PD] [n = 44] vs other diagnoses [n = 59]) and panic status (subjects who panicked [n = 28] and subjects who did not [n = 75]) during the first 5 minutes of 5% CO2 inhalation. Sex is the covariate. Statistics include the following: sex, F1,98 = 10.23, P= .002; group, F1,98 = 0.36, P= .55; panic, F1,98 = 5.25, P= .02; group × panic, F1,98 = 1.67, P= .20; time, F2.3,228 = 302.38, P<.001; group × time, F2.3,228 = 1.26, P= .29; panic × time, F2.3,228 = 1.22, P= .30; and group × panic × time, F2.3,228 = 0.33, P= .75. Date of download: 10/2/2017 Copyright © 2001 American Medical Association. All rights reserved.